A Novel Photocurable Pullulan-based Bioink for Digital Light Processing 3D Printing

Overview

Journal Int J Bioprint

Specialty Biomedical Engineering

Date 2023 May 1

PMID 37125260

Authors

Feng Zhaoxuan

Li Jinsong

Zhou Dasen

Song Hui

Lv Jiaqi

Bai Wenqin

Affiliations

Soon will be listed here.

Abstract

Digital light processing has significant advantages, such as high repeatability, low failure rate, and no extrusion shear force. To make it possible to print complex structures with high resolution, the consecutive development of photocurable ink materials is indispensable. In this work, photo-functionalized pullulan (Pul-NB) was prepared by introducing norbornene groups into pullulan chains, and an ink material suitable for photocurable printing was prepared by thiol-ene click reaction. The rheology, water absorption, and mechanical properties of the Pul-NB precursor solution and photocurable hydrogel were investigated. The optimal composition of Pul-NB ink for three-dimensional (3D) printing was obtained by adjusting the degree of substitution, Pul-NB concentration, and thiol crosslinking agent. This novel bioink for digital light processing 3D printing showed good printability and high shape fidelity. This ink material provides an excellent alternative for printing biomimetic soft tissue organs, high-throughput tissue models, soft robots, etc.

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