Mesenchymal Stem Cell Therapy for Non-healing Diabetic Foot Ulcer Infection: New Insight

Overview

Journal Front Bioeng Biotechnol

Date 2023 May 1

PMID 37122856

Authors

Golnaz Mahmoudvand

Arian Karimi Rouzbahani

Zahra Sadat Razavi

Mohamad Mahjoor

Hamed Afkhami

Affiliations

Soon will be listed here.

Abstract

Diabetic foot ulcer (DFU) is considered the most catastrophic complication of diabetes mellitus (DM), leading to repeated hospitalizations, infection, gangrene, and finally amputation of the limb. In patients suffering from diabetes mellitus, the wound-healing process is impaired due to various factors such as endothelial dysfunction and synthesis of advanced glycation end-products, hence, conventional therapeutic interventions might not be effective. With increasing therapeutic applications of mesenchymal stem cells (MSCs) in recent years, their potential as a method for improving the wound-healing process has gained remarkable attention. In this field, mesenchymal stem cells exert their beneficial effects through immunomodulation, differentiation into the essential cells at the site of ulcers, and promoting angiogenesis, among others. In this article, we review cellular and molecular pathways through which mesenchymal stem cell therapy reinforces the healing process in non-healing Diabetic foot ulcers.

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