Multi-target Antibacterial Mechanism of Ruthenium Polypyridine Complexes with Anthraquinone Groups Against

Overview

Journal RSC Med Chem

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 May 1

PMID 37122548

Authors

Li Jiang

Yuanyuan Ma

Yiman Chen

Mengcheng Cai

Zhixing Wu

Yanshi Xiong

Xuemin Duan

Xiangwen Liao

Jintao Wang

Affiliations

Soon will be listed here.

Abstract

Three new Ru(ii) complexes, [Ru(dtb)PPAD](PF) (), [Ru(dmob)PPAD](PF) () and [Ru(bpy)PPAD](PF) () (dtb = 4,4'-di-butyl-2,2'-bipyridine, dmob = 4,4'-dimethyl-2,2'-bipyridine, bpy = 2,2'-bipyridine and PPAD = 2-(pyridine-3-yl)-1-imidazo[4,5][1.10]phenanthracene-9,10-dione), were synthesized and characterized by H NMR and C NMR spectroscopy, HRMS and HPLC. Among them, showed excellent antimicrobial activity against Gram-positive bacteria (minimum inhibitory concentration (MIC) = 1 μg mL) and low hemolytic and cytotoxic activity. In addition, showed obviously rapid bactericidal activity, low resistance rate, bacterial biofilm destroying activity and high biosafety . Moreover, skin infection models and a mouse model of sepsis indicated that the anti-infective efficacy of was comparable to that of vancomycin. Mechanism exploration results showed that the antibacterial behavior is probably related with targeting of the bacterial cell membrane and inhibiting topoisomerase I.

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