Effects of Intermittent or Single High-dose Vitamin D Supplementation on Risk of Falls and Fractures: a Systematic Review and Meta-analysis

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2023 Apr 29

PMID 37120684

Authors

Seung-Kwon Myung

Heram Cho

Affiliations

Soon will be listed here.

Abstract

Purpose: Randomized controlled trials (RCTs) have reported controversial findings regarding the associations between intermittent or single high-dose vitamin D supplementation and a risk of falls and fractures in adults. This study aimed to investigate those associations using a systematic review and meta-analysis.

Methods: We searched PubMed, EMBASE, and Cochrane Library from inception to May 25, 2022. Data were extracted for a random-effects meta-analysis to calculate a pooled relative risk (RR) with a 95% confidence interval (CI).

Results: Out of 527 articles, a total of 15 RCTs were included in the final analysis. In a meta-analysis of RCTs, intermittent or single high-dose vitamin D supplementation showed no significant beneficial effect in the prevention of either falls (RR, 1.03 [95% CI, 0.98-1.09]; I = 56.6%; n = 11) or fractures (RR, 0.99 [95% CI, 0.87-1.14]; I = 48.3%; n = 11). Among the subgroup meta-analyses by various factors, intermittent or single high-dose vitamin D supplementation reduced the risk of fractures in the subgroup meta-analysis of RCTs that included fewer than 1000 participants (RR, 0.74 [95% CI 0.57-0.96]; I = 0.0%; n = 5). However, its beneficial effect was not observed in those including 1000 or more participants (RR, 1.06 [95% CI 0.92-1.21]; I = 57.5%; n = 6). In contrast, intermittent or single high-dose vitamin D3 supplementation increased the risk of falls on the borderline of statistical significance (RR, 1.06 [95% CI 0.99-1.15]; P = 0.051; I = 50.0%; n = 7).

Conclusions: Intermittent or single high-dose vitamin D supplementation had no preventive effect on the risk of falls and fractures and might even increase the risk of falls.

Citing Articles

Vitamin D and/or calcium to prevent fractures and falls: protocol for a systematic review and meta-analysis.

Masse O, Mercurio C, Dupuis S, Arruda A, Desforges K, Dugre N BMJ Open. 2024; 14(12):e085902.

PMID: 39672580 PMC: 11647347. DOI: 10.1136/bmjopen-2024-085902.

Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.

Tan L, He R, Zheng X BMC Geriatr. 2024; 24(1):390.

PMID: 38698349 PMC: 11064304. DOI: 10.1186/s12877-024-05009-x.

Maternal and Fetal Effects of Gestational Vitamin D Concentration.

Kwon K, Lee Y, Yeo M, Park S, Kim H, Kim H Healthcare (Basel). 2023; 11(16).

PMID: 37628522 PMC: 10454327. DOI: 10.3390/healthcare11162325.

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