Effects of 2-chloroadenosine on Hippocampal GABA Content and Turnover

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1986 Jan 1

PMID 3711882

Citations 2

Authors

F Zambotti

N ZONTA

P Ferrario

L Zecca

P Mantegazza

Affiliations

Soon will be listed here.

Abstract

The effects of 2-Chloroadenosine (CADO), a stable analog of adenosine, on GABA turnover rate and GABA content in the rat hippocampus in vivo have been studied. The intracerebroventricular injection of CADO reduced the GABA turnover rate in the hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase (GABA-T) by aminooxyacetic acid (AOAA). The effect of CADO on AOAA-induced accumulation of GABA in the hippocampus was blocked by the intraperitoneal injection of the adenosine receptor antagonist caffeine. Furthermore, CADO at the dose of 5 micrograms per ventricle produced a significant decrease in GABA content in the hippocampus. Our results support the hypothesis that adenosine exerts inhibitory effects on GABAergic circuits in the hippocampus.

Citing Articles

Colocalization of (3H)-adenosine accumulation and GABA immunoreactivity in the chicken and rabbit retinas.

Perez M, Bruun A Histochemistry. 1987; 87(5):413-7.

PMID: 3323143 DOI: 10.1007/BF00496812.

Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone.

Zambotti F, ZONTA N, Hafner B, Ferrario P, Zecca L, Mantegazza P Naunyn Schmiedebergs Arch Pharmacol. 1987; 335(5):547-50.

PMID: 3112588 DOI: 10.1007/BF00169122.

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