Duplication of a Manganese/cadmium Transporter Gene Reduces Cadmium Accumulation in Rice Grain

Overview

Journal Nat Food

Specialties Environmental Health
Nutritional Sciences

Date 2023 Apr 28

PMID 37118598

Authors

En Yu

Wenguang Wang

Naoki Yamaji

Shuichi Fukuoka

Jing Che

Daisei Ueno

Tsuyu Ando

Fenglin Deng

Kiyosumi Hori

Masahiro Yano

Ren Fang Shen

Jian Feng Ma

Affiliations

Soon will be listed here.

Abstract

Global contamination of soils with toxic cadmium (Cd) is a serious health threat. Here we found that a tandem duplication of a gene encoding a manganese/Cd transporter, OsNramp5, was responsible for low-Cd accumulation in Pokkali, an old rice cultivar. This duplication doubled the expression of OsNramp5 gene but did not alter its spatial expression pattern and cellular localization. Higher expression of OsNramp5 increased uptake of Cd and Mn into the root cells but decreased Cd release to the xylem. Introgression of this allele into Koshihikari, an elite rice cultivar, through backcrossing significantly reduced Cd accumulation in the grain when cultivated in soil heavily contaminated with Cd but did not affect both grain yield and eating quality. This study not only reveals the molecular mechanism underlying low-Cd accumulation but also provides a useful target for breeding rice cultivars with low-Cd accumulation.

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