Effect of Ionic Liquid on Silver-Nanoparticle-Complexed and Its Topical Film Formulation

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Apr 28

PMID 37111583

Authors

Pattwat Maneewattanapinyo

Wiwat Pichayakorn

Chaowalit Monton

Nattakan Dangmanee

Thaniya Wunnakup

Jirapornchai Suksaeree

Affiliations

Soon will be listed here.

Abstract

Imidazolium-based ionic liquids have been widely utilized as versatile solvents for metal nanoparticle preparation. Silver nanoparticles and have displayed potent antimicrobial activities. This work aimed to study the effect of 1-butyl-3-methylimidazolium bromide-based ionic liquid on the silver-nanoparticle-complexed and its topical film. The ratio and conditions for preparation were optimized by the design of the experiments. The optimal ratio was silver nanoparticles: extract: ionic liquid at 97:1:2, and the conditions were 80 °C for 1 h. The prediction was corrected with a low percentage error. The optimized formula was loaded into a topical film made of polyvinyl alcohol and Eudragit, and its properties were evaluated. The topical film was uniform, smooth, and compact and had other desired characteristics. The topical film was able to control the release of silver-nanoparticle-complexed from the matrix layer. Higuchi's model was used to fit the kinetic of the release. The skin permeability of the silver-nanoparticle-complexed was improved by about 1.7 times by the ionic liquid, which might increase solubility. The produced film is suitable for topical applications and may be utilized in the development of potential future therapeutic agents for the treatment of diseases.

Citing Articles

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review.

Zhuo Y, Cheng H, Zhao Y, Cui H Pharmaceutics. 2024; 16(1).

PMID: 38276519 PMC: 10818567. DOI: 10.3390/pharmaceutics16010151.

Imidazolium-Based Ionic Liquid-Assisted Silver Nanoparticles and Their Antibacterial Activity: Experimental and Density Functional Theory Studies.

Avirdi E, Paumo H, Kamdem B, Singh M, Kumari K, Katata-Seru L ACS Omega. 2023; 8(45):42976-42986.

PMID: 38024669 PMC: 10652719. DOI: 10.1021/acsomega.3c06171.

Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery.

Pichayakorn W, Maneewattanapinyo P, Monton C, Dangmanee N, Suksaeree J Pharmaceutics. 2023; 15(11).

PMID: 38004581 PMC: 10674566. DOI: 10.3390/pharmaceutics15112603.

Plaster Gel Loaded with Silver Nanoparticle-Mediated Ganoderma applanatum: from Fabrication to Evaluation.

Maneewattanapinyo P, Monton C, Pichayakorn W, Dangmanee N, Wunnakup T, Suksaeree J AAPS PharmSciTech. 2023; 24(5):105.

PMID: 37081249 DOI: 10.1208/s12249-023-02566-z.

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