Neuroprotective Effects of in a Chronic Neuroinflammatory Disease Model

Overview

Journal Nutrients

Date 2023 Apr 28

PMID 37111229

Authors

Seong-Lae Jo

Hyun Yang

Kang-Joo Jeong

Hye-Won Lee

Eui-Ju Hong

Affiliations

Soon will be listed here.

Abstract

Inflammation is a natural defense mechanism against noxious stimuli, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system plays an important role in the development and progression of neurodegenerative diseases. Polyphenol-rich natural products, such as (), are known to have anti-inflammatory and antioxidant properties and can provide treatment strategies for neurodegenerative diseases by controlling neuroinflammation. We investigated the effects of an extract on neuroinflammation and neurodegeneration under chronic inflammatory conditions. Mice were pretreated with extract for 19 days and then exposed to with lipopolysaccharide (LPS) for 1 week. We monitored pro-inflammatory cytokines levels in the serum, inflammation-related markers, and neurodegenerative markers using Western blotting and qRT-PCR in the mouse cerebrum and hippocampus. reduced pro-inflammatory cytokine levels in the blood and brain of mice with LPS-induced chronic inflammation. We also measured the activity of genes related to neuroinflammation and neurodegeneration. Surprisingly, decreased the activity of markers associated with inflammation (NF-kB and STAT3) and a neurodegenerative disease marker (glial fibrillary acidic protein, beta-amyloid) in the cerebrum and hippocampus of mice. We suggest that extract has the potential as a protective agent against neuroinflammation and neurodegenerative diseases.

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