Prokinetic Activity of Mulberry Fruit, L

Overview

Journal Nutrients

Date 2023 Apr 28

PMID 37111108

Authors

Tae Sik Sung

Seung-Bum Ryoo

Chang-Hyun Lee

Seon-Min Choi

Joo-Won Nam

Hyun-Bok Kim

Ji Young Lee

Jung-Dae Lim

Kyu Joo Park

Hyun-Tai Lee

Affiliations

Soon will be listed here.

Abstract

The fruit of L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR.

Citing Articles

The Impact of White Mulberry, Green Barley, Chia Seeds, and Spirulina on Physicochemical Characteristics, Texture, and Sensory Quality of Processed Cheeses.

Garbowska M, Berthold-Pluta A, Stasiak-Rozanska L, Kalisz S, Pluta A Foods. 2023; 12(15).

PMID: 37569130 PMC: 10418379. DOI: 10.3390/foods12152862.

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