Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Apr 28

PMID 37109432

Authors

Sofia Shtykalova

Dmitriy Deviatkin

Svetlana Freund

Anna Egorova

Anton Kiselev

Affiliations

Soon will be listed here.

Abstract

Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.

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