Intrauterine Infusion of Leukocyte-Poor Platelet-Rich Plasma Is an Effective Therapeutic Protocol for Patients with Recurrent Implantation Failure: A Retrospective Cohort Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Apr 28

PMID 37109159

Authors

Yanna Ban

Xiaoliang Yang

Yan Xing

Wenjun Que

Zebo Yu

Wenwu Gui

Ying Chen

Xiru Liu

Affiliations

Soon will be listed here.

Abstract

Background: The clinical application of autologous leukocyte-poor platelet-rich plasma (LP-PRP) in patients with recurrent implantation failure (RIF) is rare. This retrospective observational cohort study aimed to evaluate the efficacy of LP-PRP intrauterine infusion in patients with RIF.

Methods: Patients with RIF undergoing frozen embryo transfer (FET) from January 2019 to December 2021 ( = 118) were enrolled, with those undergoing LP-PRP intrauterine infusion as the PRP group ( = 64), and those receiving no LP-PRP treatment as the control group ( = 54). The beta-human chorionic gonadotropin (β-hCG)-positive rate, clinical pregnancy rate (CPR), live birth rate (LBR), and miscarriage rate (MR) per ET cycle were compared.

Results: The β-hCG-positive rate (57.8% vs. 38.9%, = 0.041), CPR (45.3% vs. 24.5%, = 0.022), and LBR per ET cycle (42.2% vs. 18.5%, = 0.009) were higher in the PRP group than in the control group, and the three variables (62.5% vs. 41.2%, = 0.040, 47.5% vs. 23.5%, = 0.033, and 47.5% vs. 20.6%, = 0.027) in the PRP group transferred with the were also higher than those in the control group. The MR was similar in all groups.

Conclusions: The LP-PRP treatment could improve the β-hCG-positive rate, CPR, and LBR in RIF patients undergoing FET cycles.

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