The Role of Platelets in Infective Endocarditis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Apr 28

PMID 37108707

Authors

Mustapha Abdeljalil Brai

Nadji Hannachi

Nabila El Gueddari

Jean-Pierre Baudoin

Abderrhamane Dahmani

Hubert Lepidi

Gilbert Habib

Laurence Camoin-Jau

Affiliations

Soon will be listed here.

Abstract

Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the pathogenesis of IE. The pathogenesis of endocarditis is so complex and atypical that it is still unclear how and why certain bacterial species will induce the formation of vegetation. In this review, we will analyze the key role of platelets in the physiopathology of endocarditis and in the formation of vegetation, depending on the bacterial species. We provide a comprehensive outline of the involvement of platelets in the host immune response, investigate the latest developments in platelet therapy, and discuss prospective research avenues for solving the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.

Citing Articles

Embolic risk management in infective endocarditis: predicting the 'embolic roulette'.

Serban A, Pepine D, Inceu A, Dadarlat A, Achim A Open Heart. 2025; 12(1).

PMID: 39890159 PMC: 11792284. DOI: 10.1136/openhrt-2024-003060.

Bacterial Diversity in Native Heart Valves in Infective Endocarditis.

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PMID: 39857828 PMC: 11762347. DOI: 10.3390/biomedicines13010245.

Enterococcal-host interactions in the gastrointestinal tract and beyond.

Madani W, Ramos Y, Cubillos-Ruiz J, Morales D FEMS Microbes. 2024; 5:xtae027.

PMID: 39391373 PMC: 11466040. DOI: 10.1093/femsmc/xtae027.

Current Knowledge of Enterococcal Endocarditis: A Disease Lurking in Plain Sight of Health Providers.

Nappi F Pathogens. 2024; 13(3).

PMID: 38535578 PMC: 10974565. DOI: 10.3390/pathogens13030235.

Understanding -Associated Infective Endocarditis: Examining Heart Valve and Vegetation Appearance and the Role of Neutrophilic Leukocytes.

Meidrops K, Groma V, Goldins N, Apine L, Skuja S, Svirskis S Cells. 2024; 13(1).

PMID: 38201247 PMC: 10778237. DOI: 10.3390/cells13010043.

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