The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Apr 28

PMID 37108257

Authors

Micaela Berni

Alice Maria Brancato

Camilla Torriani

Valentina Bina

Salvatore Annunziata

Elena Cornella

Michelangelo Trucchi

Eugenio Jannelli

Mario Mosconi

Giulia Gastaldi

Laura Caliogna

Federico Alberto Grassi

Gianluigi Pasta

Affiliations

Soon will be listed here.

Abstract

Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.

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