Identification and Functional Analysis of and in Anti-Bacterial Infection of

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Apr 28

PMID 37107584

Authors

Ze-Chang Bian

Xiao-Hui Cai

Kian Ann Tan

Ya-Dan Wang

Zhuang Huang

Kit Yue Kwan

Peng Xu

Affiliations

Soon will be listed here.

Abstract

Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP) are a group of antibacterial proteins that play an important role in the host's innate immune defense against pathogen infection. In this study, two BPI/LBPs, named (1434 bp in length, 478 amino acids) and (1422 bp in length, 474 amino acids), were identified from the golden pompano. and were significantly expressed in immune-related tissues after being challenged with and . The two BPI/LBPs showed significant antibacterial activity against Gram-negative and Gram-positive and . In contrast, the antibacterial activity against , , , and was low and decreased with time. The membrane permeability of bacteria treated with recombinant ToBPI1/LBP and ToBPI2/LBP was significantly enhanced. These results suggest that ToBPI1/LBP and ToBPI2/LBP may play important immunological roles in the immune response of the golden pompano to bacteria. This study will provide basic information and new insights into the immune response mechanism of the golden pompano to bacteria and the function of BPI/LBP.

Citing Articles

Bactericidal Permeability-Increasing Protein (BPI) Inhibits Growth.

Guzman-Beltran S, Juarez E, Cruz-Munoz B, Paez-Cisneros C, Sarabia C, Gonzalez Y Biomolecules. 2024; 14(4).

PMID: 38672491 PMC: 11048543. DOI: 10.3390/biom14040475.

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