Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Strains

Overview

Journal Antioxidants (Basel)

Date 2023 Apr 28

PMID 37107174

Authors

Jisun Yang

Hyeijin Cho

Minchan Gil

Kyung Eun Kim

Affiliations

Soon will be listed here.

Abstract

Maca is a well-known biennial herb with various physiological properties, such as antioxidant activity and immune response regulation. In this study, the antioxidant, anti-inflammatory, and anti-melanogenic effects of fermented maca root extracts were investigated. The fermentation was carried out using strains, such as , , , and . In RAW 264.7 cells, the non-fermented maca root extracts increased the secretion of nitric oxide (NO), an inflammatory mediator, in a dose-dependent manner. In contrast, the fermented extracts showed considerably lower NO secretion than the non-fermented extracts at concentrations of 5% and 10%. This indicates the effective anti-inflammatory effects of fermented maca. The fermented maca root extracts also inhibited tyrosinase activity, melanin synthesis, and melanogenesis by suppressing MITF-related mechanisms. These results show that fermented maca root extracts exhibit higher anti-inflammatory and anti-melanogenesis effects than non-fermented maca root extracts. Thus, maca root extracts fermented using strains have the potential to be used as an effective cosmeceutical raw material.

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