Evidence for Prepulse Inhibition of Visually Evoked Motor Response in

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2023 Apr 28

PMID 37106835

Authors

Helgi B Schioth

Laura Donzelli

Nicklas Arvidsson

Michael J Williams

Thiago C Moulin

Affiliations

Soon will be listed here.

Abstract

Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult . In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.

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