Inhaled Antihistamines--bronchodilatation and Effects on Histamine- and Methacholine-induced Bronchoconstriction

Overview

Journal Thorax

Date 1978 Dec 1

PMID 371057

Citations 16

Authors

S G Nogrady

C Bevan

Affiliations

Soon will be listed here.

Abstract

To assess further the bronchodilator activity of inhaled antihistamines ten stable asthmatic subjects inhaled aerosols of clemastine, 1 mg/ml, and saline placebo administered double blind. Subjects underwent bronchial challenge with increasing concentrations of histamine and methacholine, and specific airways conductance was measured by whole body plethysmography at each concentration. There was a significant 21.9% increase in specific airways conductance after inhalation of clemastine. Subjects could tolerate significantly higher mean concentrations of histamine when treated with clemastine than with saline. The shift of the cumulative log histamine dose-reponse curve suggests that such protection is due to competitive antagonism to the inhaled clemastine. Clemastine did not protect subjects against methacholine-induced bronchoconstriction, which suggests that its bronchodilator properties are not related to any anticholinergic action.

Citing Articles

Methacholine challenge testing: comparative pharmacology.

Davis B, Blais C, Cockcroft D J Asthma Allergy. 2018; 11:89-99.

PMID: 29785128 PMC: 5957064. DOI: 10.2147/JAA.S160607.

Multiple exercise and histamine challenge in asthmatic patients.

Schoeffel R, Anderson S, GILLAM I, Lindsay D Thorax. 1980; 35(3):164-70.

PMID: 7385088 PMC: 471248. DOI: 10.1136/thx.35.3.164.

Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects.

Hartmann V, Magnussen H, Holle J, Schuler E Thorax. 1981; 36(10):737-40.

PMID: 7330790 PMC: 471746. DOI: 10.1136/thx.36.10.737.

H2 receptor blockade and bronchial hyperreactivity to histamine in asthma.

Nogrady S, Bevan C Thorax. 1981; 36(4):268-71.

PMID: 7281094 PMC: 471489. DOI: 10.1136/thx.36.4.268.

Relationship between asthma and gastro-oesophageal reflux.

Goodall R, Earis J, Cooper D, Bernstein A, Temple J Thorax. 1981; 36(2):116-21.

PMID: 7022737 PMC: 471453. DOI: 10.1136/thx.36.2.116.

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