Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2023 Apr 27

PMID 37103352

Authors

Bhuvi Sachdeva

Punya Sachdeva

Arvind Negi

Shampa Ghosh

Sungsoo Han

Saikat Dewanjee

Saurabh Kumar Jha

Rakesh Bhaskar

Jitendra Kumar Sinha

Ana Claudia Paiva-Santos

Niraj Kumar Jha

Kavindra Kumar Kesari

Affiliations

Soon will be listed here.

Abstract

Chitin is the second most abundant biopolymer consisting of -acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.

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