Waist Circumference As a Risk Factor for Non-Alcoholic Fatty Liver Disease in Older Adults in Guayaquil, Ecuador

Overview

Journal Geriatrics (Basel)

Specialty Geriatrics

Date 2023 Apr 27

PMID 37102968

Authors

Dayana Cabrera

Jorge Moncayo-Rizzo

Karen Cevallos

Geovanny Alvarado-Villa

Affiliations

Soon will be listed here.

Abstract

Methods: A cross-sectional study was carried out in 99 older adults who regularly attended five gerontological centers in the city of Guayaquil, Ecuador. The variables studied were age, gender, independent life, access to complete meals, waist circumference, and NAFLD diagnosed by ultrasound.

Results: A significant relationship exists between waist circumference, body mass index, and fat mass percentage. However, only age and waist circumference were significant in the multivariate logistic regression model. Our results suggest that in the presence of waist circumference, body mass index loses its significance and age may be a protective factor due to adipose tissue loss and redistribution.

Conclusion: Anthropometric measurements such as waist circumference can be used as complement indicators of NAFLD.

Citing Articles

Diagnostic accuracy of Fatty Liver Index (FLI) for detecting Metabolic Associated Fatty Liver Disease (MAFLD) in adults attending a tertiary care hospital, a cross-sectional study.

Vamja R, M Y, Vala V, Ramachandran A, Nagda J Clin Diabetes Endocrinol. 2024; 10(1):46.

PMID: 39668382 PMC: 11639111. DOI: 10.1186/s40842-024-00197-2.

The Combination of Remnant Cholesterol and Waist Circumference Offers Predictive Value for Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study from a Medical Examination Center.

Jia Z, Pan X, Chen S Diabetes Metab Syndr Obes. 2023; 16:3459-3469.

PMID: 37937236 PMC: 10627089. DOI: 10.2147/DMSO.S429963.

References

Ma X, Holalkere N, Kambadakone R A, Mino-Kenudson M, Hahn P, Sahani D . Imaging-based quantification of hepatic fat: methods and clinical applications. Radiographics. 2009; 29(5):1253-77. DOI: 10.1148/rg.295085186. View

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View

Lazarus J, Colombo M, Cortez-Pinto H, Huang T, Miller V, Ninburg M . NAFLD - sounding the alarm on a silent epidemic. Nat Rev Gastroenterol Hepatol. 2020; 17(7):377-379. DOI: 10.1038/s41575-020-0315-7. View

Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G . Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 2011; 54(1):133-44. PMC: 4158408. DOI: 10.1002/hep.24341. View

Albhaisi S, Chowdhury A, Sanyal A . Non-alcoholic fatty liver disease in lean individuals. JHEP Rep. 2020; 1(4):329-341. PMC: 7001558. DOI: 10.1016/j.jhepr.2019.08.002. View

Uematsu T, Kasami M, Kiyohara Y . B-Mode Ultrasound Imaging, Doppler Imaging, and Real-Time Elastography in Cutaneous Malignant Melanoma and Lymph Node Metastases. Healthcare (Basel). 2016; 1(1):84-95. PMC: 4934507. DOI: 10.3390/healthcare1010084. View

Milic S, Lulic D, Stimac D . Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. World J Gastroenterol. 2014; 20(28):9330-7. PMC: 4110564. DOI: 10.3748/wjg.v20.i28.9330. View

Petzold G . Role of Ultrasound Methods for the Assessment of NAFLD. J Clin Med. 2022; 11(15). PMC: 9369745. DOI: 10.3390/jcm11154581. View

Polyzos S, Kountouras J, Mantzoros C . Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics. Metabolism. 2018; 92:82-97. DOI: 10.1016/j.metabol.2018.11.014. View

10.

Golabi P, Paik J, Reddy R, Bugianesi E, Trimble G, Younossi Z . Prevalence and long-term outcomes of non-alcoholic fatty liver disease among elderly individuals from the United States. BMC Gastroenterol. 2019; 19(1):56. PMC: 6469055. DOI: 10.1186/s12876-019-0972-6. View

11.

Kelley D, McKolanis T, Hegazi R, Kuller L, Kalhan S . Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab. 2003; 285(4):E906-16. DOI: 10.1152/ajpendo.00117.2003. View

12.

Jones G, Graubard B, Alvarez C, McGlynn K . Prediction of nonalcoholic fatty liver disease using anthropometry and body fat measures by sex and race/ethnicity in the United States. Obesity (Silver Spring). 2022; 30(9):1760-1765. DOI: 10.1002/oby.23514. View

13.

Ludwig J, Viggiano T, MCGILL D, Oh B . Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980; 55(7):434-8. View

14.

Tsai J, Ferrell L, Tan V, Yeh M, Sarkar M, Gill R . Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Mod Pathol. 2017; 30(6):834-842. PMC: 5935795. DOI: 10.1038/modpathol.2017.13. View

15.

Chao Y, Chen W, Peng T, Wu L, Liaw F, Kao T . Examining the association between muscle mass, muscle function, and fat indexes in an elderly population. Nutrition. 2020; 83:111071. DOI: 10.1016/j.nut.2020.111071. View

16.

Kupusinac A, Stokic E, Doroslovacki R . Predicting body fat percentage based on gender, age and BMI by using artificial neural networks. Comput Methods Programs Biomed. 2013; 113(2):610-9. DOI: 10.1016/j.cmpb.2013.10.013. View

17.

Jimenez-Cruz A, Gomez-Miranda L, Diaz Ramirez G, Carvali Meza N, Bacardi-Gascon M . [Adiposity as a risk factor of non alcoholic fat disease; systematic review]. Nutr Hosp. 2014; 29(4):771-5. DOI: 10.3305/nh.2014.29.4.7216. View

18.

Moctezuma-Velazquez C . Current treatment for non-alcoholic fatty liver disease. Rev Gastroenterol Mex (Engl Ed). 2018; 83(2):125-133. DOI: 10.1016/j.rgmx.2017.10.003. View

19.

Fang H, Judd R . Adiponectin Regulation and Function. Compr Physiol. 2018; 8(3):1031-1063. DOI: 10.1002/cphy.c170046. View

20.

Younossi Z, Koenig A, Abdelatif D, Fazel Y, Henry L, Wymer M . Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2015; 64(1):73-84. DOI: 10.1002/hep.28431. View