Discovery of a New Chemical Scaffold for the Treatment of Superbug Infections

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2023 Apr 27

PMID 37102336

Authors

Jie Tu

Tianbao Zhu

Qingwen Wang

Wanzhen Yang

Yahui Huang

DeFeng Xu

Na Liu

Chunquan Sheng

Affiliations

Soon will be listed here.

Abstract

has emerged as a serious threat of public health and caused global epidemic due to multi-drug resistance, remarkable transmissibility and high mortality. To tackle the challenging super fungus, novel benzoanilide antifungal agents were discovered by an integrated strategy of phenotypic screen, hit optimization, antifungal assays and mechanism exploration. The most promising compound showed potent and efficacy against infection. Mechanism investigation revealed that compound blocked the biosynthesis of virulence factors and fungal cell walls through the inhibition of glycosylphosphatidylinositol (GPI) and GPI-anchored proteins. Thus, compound represents a promising lead compound to combat drug-resistant candidiasis.

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