3D Raman Mapping As an Analytical Tool for Investigating the Coatings of Coated Drug Particles

Overview

Journal J Pharm Anal

Specialty Chemistry

Date 2023 Apr 27

PMID 37102110

Authors

Georgia Koutentaki

Pavel Krysa

Dan Trunov

Tomas Pekarek

Marketa Pislova

Miroslav Soos

Affiliations

Soon will be listed here.

Abstract

The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating agent (dissolution retardant) were investigated. Raman mapping technique was used to non-destructively examine the thickness and homogeneity of coated particles. The results showed that the wax existed in two forms on the surface of the paracetamol particles, forming a porous coating layer: i) whole wax particles on the surface of paracetamol and glued together with other wax surface particles, and ii) deformed wax particles spread on the surface. Regardless of the final particle size fraction (between 100 and 800 μm), the coating thickness had high variability, with average thickness of 5.9 ± 4.2 μm. The ability of carnauba wax to decrease the dissolution rate of paracetamol was confirmed by dissolution of powder and tablet formulations. The dissolution was slower for larger coated particles. Tableting further reduced the dissolution rate, clearly indicating the impact of subsequent formulation processes on the final quality of the product.

Citing Articles

Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging.

Dunnington E, Wong B, Fu D Anal Chem. 2024; 96(20):7926-7944.

PMID: 38625100 PMC: 11108735. DOI: 10.1021/acs.analchem.4c01413.

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