Gender Differences in the Association Between Cholesteryl Esters Transfer Protein Polymorphism (rs708272) and Plasma Lipid Levels in Hyperlipidaemic Participants at Hospital Universiti Sains Malaysia

Overview

Journal Malays J Med Sci

Specialty General Medicine

Date 2023 Apr 27

PMID 37102051

Authors

Amirul Faez Shamsudin

Nur Salwani Bakar

Affiliations

Soon will be listed here.

Abstract

Background: Single nucleotide polymorphism (SNP) in the () gene (rs708272) was reported to affect statin efficacy. This study investigated the association between rs708272 and statin's lipid-lowering effects in hyperlipidaemic participants at Hospital Universiti Sains Malaysia, Kelantan.

Methods: A total of 229 hyperlipidaemic statin users (96.1% Malays) were recruited, and a single blood sample (3 mL) was obtained for DNA extraction. The genotypes were determined using PCR-RFLP method and validated by sequencing analysis.

Results: The minor allele frequency for rs708272 in all participants was 0.391, with no difference between females and males. At the baseline, the SNP was associated with different low-density lipoprotein (LDL-c) and triglyceride (TG) levels in females, but not males, when the GG and GA+AA genotypes were compared using a dominant genetic model. Regardless of the genotype, the total cholesterol and LDL-c levels decreased significantly ( < 0.001) in both genders after statin treatment, but the TG levels decreased exclusively in females with the GG genotypes. In both genders, high density lipoprotein levels were unaffected before and after the statin treatment.

Conclusion: To improve the management of hyperlipidaemia, future research should consider patient gender when assessing the rs708272 impact on LDL-c and TG.

Citing Articles

Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update.

Dabravolski S, Orekhov N, Melnichenko A, Sukhorukov V, Popov M, Orekhov A Curr Pharm Des. 2024; 30(10):742-756.

PMID: 38425105 DOI: 10.2174/0113816128284695240219093612.

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