Prevalence and Risk Factors of Allergic Diseases Among School Students in Tabuk: A Cross-Sectional Study

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2023 Apr 27

PMID 37101984

Authors

Amirah M Alatawi

Abeer Mohammed M Alanazi

Amjad Bader S Almutairi

Raghad Faraih A Albalawi

Asmaa Abdullah M Alhakami

Aljoharh Abdulaziz S Alnuaman

Lena Defallah D Alzahrani

Ziad Saleh Albalwi

Abeer Ali H Alabawy

Lama Mueysh M Aljohani

Nouf Ali S Alatawi

Affiliations

Soon will be listed here.

Abstract

Background: Allergic diseases such as bronchial asthma, allergic rhinitis, and atopic dermatitis are common health problems among children. The prevalence of different allergic diseases is increasing in the Kingdom of Saudi Arabia.

Objectives: This study aimed to estimate the prevalence and risk factors of allergic diseases among school students in Tabuk, Saudi Arabia.

Methods: This cross-sectional analytical study was conducted in Tabuk city, Saudi Arabia, between the first of August and the end of September, 2022. Students from primary, intermediate, and secondary schools were included. A predesigned, structured, self-administered questionnaire in the Arabic language was used to collect data.

Results: This study included 384 school students from Tabuk, Saudi Arabia. The age of the recruited students ranged from five to 19 years old. The prevalence of clinically diagnosed bronchial asthma that occurred at any time in the past was 31.8%. The prevalence of asthma symptoms was 51.0% for lifetime wheezing and 45.8% for current wheezing (in the past 12 months). The prevalence rates of clinically diagnosed allergic rhinitis and atopic dermatitis were 56.8% and 30.2%, respectively. Further, 68.2% of the school students had one or more of the diagnosed allergic diseases. The second or more childbirth orders were significantly associated with an increased risk of allergic diseases (adjusted odds ratio [AOR] = 3.140, 95% CI: 1.864-5.288). A family history of asthma or atopic conditions showed 3.118 times increased likelihood of allergic conditions (AOR = 3.118, 95% CI: 1.827-5.320). Other significant risk factors were the father's smoking (AOR = 1.698, 95% CI: 1.024-2.817) and having a dog, cat, or bird at home (AOR = 0.493, 95% CI: 0.257-0.946).

Conclusion: The prevalence of bronchial asthma and other allergic diseases such as allergic rhinitis and atopic dermatitis among school students in Tabuk city, Saudi Arabia, is alarmingly high. Furthermore, both genetic and environmental components of allergic disease pathogenesis have been identified as risk factors.

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References

Thacher J, Gruzieva O, Pershagen G, Neuman A, van Hage M, Wickman M . Parental smoking and development of allergic sensitization from birth to adolescence. Allergy. 2015; 71(2):239-48. PMC: 5063181. DOI: 10.1111/all.12792. View

Alshehri M, Abolfotouh M, Sadeg A, Al Najjar Y, Asindi A, Al Harthi A . Screening for asthma and associated risk factors among urban school boys in Abha city. Saudi Med J. 2001; 21(11):1048-53. View

Mak K, Ho R, Day J . The associations of asthma symptoms with active and passive smoking in Hong Kong adolescents. Respir Care. 2012; 57(9):1398-404. DOI: 10.4187/respcare.01548. View

Aburiziza A, Almatrafi M, Alonazi A, Zatari M, Alqouzi S, Abdulaziz Mandili R . The Prevalence, Clinical Picture, and Triggers of Allergic Rhinitis in Saudi Population: A Systematic Review and Meta-Analysis. J Asthma Allergy. 2022; 15:1831-1849. PMC: 9793734. DOI: 10.2147/JAA.S391142. View

Alshammrie F, Albarrak S, Alhuthaili A, Alakash S, Al Mansour M, Gammash M . Prevalence and Influencing Risk Factors of Eczema Among Preschool Children in Hail City. Cureus. 2023; 14(12):e32723. PMC: 9851571. DOI: 10.7759/cureus.32723. View

Mazur M, Czarnobilska M, Dyga W, Czarnobilska E . Trends in the Epidemiology of Allergic Diseases of the Airways in Children Growing Up in an Urban Agglomeration. J Clin Med. 2022; 11(8). PMC: 9031390. DOI: 10.3390/jcm11082188. View

Al-Moamary M, Alhaider S, Idrees M, Al Ghobain M, Zeitouni M, Al-Harbi A . The Saudi Initiative for Asthma - 2016 update: Guidelines for the diagnosis and management of asthma in adults and children. Ann Thorac Med. 2016; 11(1):3-42. PMC: 4748613. DOI: 10.4103/1817-1737.173196. View

Pols D, Wartna J, van Alphen E, Moed H, Rasenberg N, Bindels P . Interrelationships between Atopic Disorders in Children: A Meta-Analysis Based on ISAAC Questionnaires. PLoS One. 2015; 10(7):e0131869. PMC: 4489894. DOI: 10.1371/journal.pone.0131869. View

Abdulrahman H, Hadi U, Tarraf H, Gharagozlou M, Kamel M, Soliman A . Nasal allergies in the Middle Eastern population: Results from the "Allergies in Middle East Survey". Am J Rhinol Allergy. 2017; 26(6):3-23. DOI: 10.2500/ajra.2012.26.3836. View

10.

Musharrafieh U, Tamim H, Houry R, AlBuhairan F . A nationwide study of asthma correlates among adolescents in Saudi Arabia. Asthma Res Pract. 2020; 6:3. PMC: 7262750. DOI: 10.1186/s40733-020-00056-8. View

11.

Al Ghobain M, Al-Hajjaj M, Al Moamary M . Asthma prevalence among 16- to 18-year-old adolescents in Saudi Arabia using the ISAAC questionnaire. BMC Public Health. 2012; 12:239. PMC: 3384472. DOI: 10.1186/1471-2458-12-239. View

12.

Kim Y, Kim H, Ahn H, Sohn T, Song J, Lee Y . The Association between Tobacco Smoke and Serum Immunoglobulin E Levels in Korean Adults. Intern Med. 2017; 56(19):2571-2577. PMC: 5658521. DOI: 10.2169/internalmedicine.8737-16. View

13.

Badloe F, De Vriese S, Coolens K, Schmidt-Weber C, Ring J, Gutermuth J . IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis. Clin Transl Allergy. 2020; 10:34. PMC: 7398196. DOI: 10.1186/s13601-020-00338-7. View

14.

Aldakheel F . Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics. Int J Environ Res Public Health. 2021; 18(22). PMC: 8622387. DOI: 10.3390/ijerph182212105. View

15.

Almatroudi A, Mousa A, Vinnakota D, Abalkhail A, Alwashmi A, Almatroodi S . Prevalence and associated factors of respiratory allergies in the Kingdom of Saudi Arabia: A cross-sectional investigation, September-December 2020. PLoS One. 2021; 16(6):e0253558. PMC: 8221486. DOI: 10.1371/journal.pone.0253558. View

16.

Ibrahim N, Almarzouqi F, Al Melaih F, Farouk H, Alsayed M, AlJassim F . Prevalence of asthma and allergies among children in the United Arab Emirates: A cross-sectional study. World Allergy Organ J. 2021; 14(10):100588. PMC: 8503660. DOI: 10.1016/j.waojou.2021.100588. View

17.

Ray C, Ming X . Climate Change and Human Health: A Review of Allergies, Autoimmunity and the Microbiome. Int J Environ Res Public Health. 2020; 17(13). PMC: 7369820. DOI: 10.3390/ijerph17134814. View

18.

Nahhas M, Bhopal R, Anandan C, Elton R, Sheikh A . Prevalence of allergic disorders among primary school-aged children in Madinah, Saudi Arabia: two-stage cross-sectional survey. PLoS One. 2012; 7(5):e36848. PMC: 3355178. DOI: 10.1371/journal.pone.0036848. View

19.

Behbehani N, Abal A, Syabbalo N, Abd Azeem A, Shareef E, Al-Momen J . Prevalence of asthma, allergic rhinitis, and eczema in 13- to 14-year-old children in Kuwait: an ISAAC study. International Study of Asthma and Allergies in Childhood. Ann Allergy Asthma Immunol. 2000; 85(1):58-63. DOI: 10.1016/s1081-1206(10)62435-0. View

20.

Sio Y, Chew F . Risk factors of asthma in the Asian population: a systematic review and meta-analysis. J Physiol Anthropol. 2021; 40(1):22. PMC: 8662898. DOI: 10.1186/s40101-021-00273-x. View