Clinico-imaging Features of Subjects at Risk of Lewy Body Disease in NaT-PROBE Baseline Analysis

Overview

Journal NPJ Parkinsons Dis

Date 2023 Apr 26

PMID 37100802

Authors

Makoto Hattori

Keita Hiraga

Yuki Satake

Takashi Tsuboi

Daigo Tamakoshi

Maki Sato

Katsunori Yokoi

Keisuke Suzuki

Yutaka Arahata

Akihiro Hori

Motoshi Kawashima

Hideaki Shimizu

Hiroshi Matsuda

Katsuhiko Kato

Yukihiko Washimi

Masahisa Katsuno

Affiliations

Soon will be listed here.

Abstract

Individuals with prodromal symptoms of Lewy body disease (LBD), such as rapid eye movement sleep behavior disorder (RBD), often showed imaging defects similar to patients with Parkinson's disease and dementia with Lewy bodies. We examined dopamine transporter (DaT) single-photon-emission computed tomography (SPECT) and metaiodobenzylguanidine (MIBG) scintigraphy in 69 high-risk subjects with ≥2 prodromal symptoms (dysautonomia, hyposmia, and probable RBD) and 32 low-risk subjects without prodromal symptoms, whom were identified through a questionnaire survey of health checkup examinees. The high-risk subjects had significantly worse scores on Stroop test, line orientation test, and the Odor Stick Identification Test for Japanese than the low-risk subjects. The prevalence of abnormalities on DaT-SPECT was higher in the high-risk group than in the low-risk group (24.6% vs. 6.3%, p = 0.030). A decreased uptake on DaT-SPECT was associated with motor impairment, and MIBG scintigraphy defects were associated with hyposmia. The simultaneous evaluation of DaT-SPECT and MIBG scintigraphy may capture a wide range of individuals with prodromal LBD.

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