ClC Chloride Channels in Gram-Negative Bacteria and Its Role in the Acid Resistance Systems

Overview

Journal J Microbiol Biotechnol

Specialties Biotechnology
Microbiology

Date 2023 Apr 26

PMID 37100762

Authors

MinJeong Kim

Nakjun Choi

Eunna Choi

Eun-Jin Lee

Affiliations

Soon will be listed here.

Abstract

Pathogenic bacteria that colonize the human intestinal tract have evolved strategies to overcome acidic conditions when they pass through the gastrointestinal tract. Amino acid-mediated acid resistance systems are effective survival strategies in a stomach that is full of amino acid substrate. The amino acid antiporter, amino acid decarboxylase, and ClC chloride antiporter are all engaged in these systems, and each one plays a role in protecting against or adapting to the acidic environment. The ClC chloride antiporter, a member of the ClC channel family, eliminates negatively charged intracellular chloride ions to avoid inner membrane hyperpolarization as an electrical shunt of the acid resistance system. In this review, we will discuss the structure and function of the prokaryotic ClC chloride antiporter of amino acid-mediated acid resistance system.

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