Dose-dependent Effects of Taurine Against Testicular Damage in a Streptozotocin-induced Type 1 Diabetes Mellitus Rat Model

Overview

Journal Int J Immunopathol Pharmacol

Publisher Sage Publications

Specialties Allergy & Immunology
Pathology
Pharmacology

Date 2023 Apr 26

PMID 37099672

Authors

Ahmed H Elbanna

Afaf S Osman

Amira Hossny

Hossny ElBanna

Fatma I Abo El-Ela

Affiliations

Soon will be listed here.

Abstract

Objectives: Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine's possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes.

Methods: Wistar rats ( = 56) were divided into seven equal groups. Untreated control rats received saline, and treated control rats received taurine 50 mg/kg orally. To induce diabetes, rats received a single dose of streptozotocin. Metformin-treated diabetic rats received metformin at a dose of 300 mg/kg. Taurine-treated groups received 10, 25, or 50 mg/kg. All treatments were provided orally once a day for 9 weeks following the streptozotocin injection. Levels of blood glucose, serum insulin, cholesterol, testicular tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL-1β), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), and catalase (CAT) were examined. Sperm count, progressive sperm motility, and sperm abnormalities were examined. Body and relative reproductive gland weights were assessed. Histopathological examinations of the testes and epididymis were performed.

Results: Metformin as well as taurine (in a dose-dependent manner) resulted in significant improvements in body and relative reproductive gland weights, blood glucose, serum cholesterol, and insulin levels, as well as cytokine and oxidative parameters. These findings were associated with significant improvement in sperm count, progressive sperm motility, sperm abnormalities, and histopathological lesions in the testes and epididymis.

Conclusion: Taurine can potentially improve hyperglycemia, hypercholesterolemia, and testicular damage associated with diabetes mellitus, possibly by controlling inflammation and oxidative stress.

Citing Articles

Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role.

Emil A, Hassan N, Ibrahim S, Hassanen E, Eldin Z, Ali S Sci Rep. 2024; 14(1):30607.

PMID: 39715797 PMC: 11666763. DOI: 10.1038/s41598-024-81949-z.

Piperazine ferulate impact on diabetes-induced testicular dysfunction: unveiling genetic insights, MAPK/ERK/JNK pathways, and TGF-β signaling.

Abdel-Wahab B, El-Shoura E, Habeeb M, Aldabaan N, Ahmed Y, Zaafar D Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39671097 DOI: 10.1007/s00210-024-03654-y.

Esculeoside A alleviates reproductive toxicity in streptozotocin-diabetic rats' s model by activating Nrf2 signaling.

AlTamimi J, AlFaris N, Alshammari G, Alagal R, Aljabryn D, Yahya M Saudi J Biol Sci. 2023; 30(9):103780.

PMID: 37663394 PMC: 10472313. DOI: 10.1016/j.sjbs.2023.103780.

References

Malavige L, Levy J . Erectile dysfunction in diabetes mellitus. J Sex Med. 2009; 6(5):1232-47. DOI: 10.1111/j.1743-6109.2008.01168.x. View

Chen S, Kong W, Zhang Y, Li Y, Mi X, Mu X . Possible anxiolytic effects of taurine in the mouse elevated plus-maze. Life Sci. 2004; 75(12):1503-11. DOI: 10.1016/j.lfs.2004.03.010. View

Yao H, Lin P, Chang Y, Chen C, Chiang M, Chang L . Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food Chem Toxicol. 2009; 47(7):1703-9. DOI: 10.1016/j.fct.2009.04.030. View

Haber C, Lam T, Yu Z, Gupta N, Goh T, Bogdanovic E . N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab. 2003; 285(4):E744-53. DOI: 10.1152/ajpendo.00355.2002. View

Lichtenstein A, CHOBANIAN A . Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit. Arteriosclerosis. 1990; 10(4):597-606. DOI: 10.1161/01.atv.10.4.597. View

Schuster D, Duvuuri V . Diabetes mellitus. Clin Podiatr Med Surg. 2002; 19(1):79-107. DOI: 10.1016/S0891-8422(03)00082-X. View

Liu H, Lin S, Lv Q, Yang Q, Wu G, Hu J . Taurine Recovers Testicular Steroidogenesis and Spermatogenesis in Streptozotocin-Induced Diabetic Rats. Adv Exp Med Biol. 2017; 975 Pt 2:801-811. DOI: 10.1007/978-94-024-1079-2_62. View

Arany E, Strutt B, Romanus P, Remacle C, Reusens B, Hill D . Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia. 2004; 47(10):1831-7. DOI: 10.1007/s00125-004-1535-z. View

Schaalan M, Ramadan B, Elwahab A . Synergistic effect of carnosine on browning of adipose tissue in exercised obese rats; a focus on circulating irisin levels. J Cell Physiol. 2017; 233(6):5044-5057. DOI: 10.1002/jcp.26370. View

10.

Saleh A, Roy Chowdhury S, Smith D, Balakrishnan S, Tessler L, Martens C . Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents. Neuropharmacology. 2012; 65:65-73. PMC: 3521091. DOI: 10.1016/j.neuropharm.2012.09.015. View

11.

Verma L, Singour P, Chaurasiya P, Rajak H, Pawar R, Patil U . Effect of ethanolic extract of Cassia occidentalis Linn. for the management of alloxan-induced diabetic rats. Pharmacognosy Res. 2011; 2(3):132-7. PMC: 3141303. DOI: 10.4103/0974-8490.65506. View

12.

Rask-Madsen C, King G . Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2006; 3(1):46-56. DOI: 10.1038/ncpendmet0366. View

13.

Sobrido-Camean D, Fernandez-Lopez B, Pereiro N, Lafuente A, Rodicio M, Barreiro-Iglesias A . Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys. J Neurotrauma. 2019; 37(6):899-903. DOI: 10.1089/neu.2019.6604. View

14.

Kilarkaje N, Al-Bader M . Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis. Reprod Sci. 2014; 22(1):102-12. PMC: 4275448. DOI: 10.1177/1933719114533729. View

15.

Vettorazzi J, Ribeiro R, Santos-Silva J, Borck P, Batista T, Nardelli T . Taurine supplementation increases K(ATP) channel protein content, improving Ca2+ handling and insulin secretion in islets from malnourished mice fed on a high-fat diet. Amino Acids. 2014; 46(9):2123-36. DOI: 10.1007/s00726-014-1763-6. View

16.

Kim H, Lee A, You S, Park T, Lee D . Characterization of taurine as inhibitor of sodium glucose transporter. Adv Exp Med Biol. 2006; 583:137-45. DOI: 10.1007/978-0-387-33504-9_14. View

17.

El-Seweidy M, El-Swefy S, Ameen R, Hashem R . Effect of age receptor blocker and/or anti-inflammatory coadministration in relation to glycation, oxidative stress and cytokine production in stz diabetic rats. Pharmacol Res. 2002; 45(5):391-8. DOI: 10.1006/phrs.2002.0979. View

18.

Das J, Ghosh J, Manna P, Sil P . Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochem Pharmacol. 2011; 81(7):891-909. DOI: 10.1016/j.bcp.2011.01.008. View

19.

Brons C, Spohr C, Storgaard H, Dyerberg J, Vaag A . Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus. Eur J Clin Nutr. 2004; 58(9):1239-47. DOI: 10.1038/sj.ejcn.1601955. View

20.

Azab S, Kamel I, Nabil Ismail N, El Din Hosni H, El Fatah M . The defensive role of taurine against gonadotoxicity and testicular apoptosis effects induced by cisplatin in rats. J Infect Chemother. 2019; 26(1):51-57. DOI: 10.1016/j.jiac.2019.07.004. View