Unlocking the Mystery Associated with Infertility and Prostate Cancer: an Update

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2023 Apr 26

PMID 37099242

Authors

Anirban Goutam Mukherjee

Abilash Valsala Gopalakrishnan

Affiliations

Soon will be listed here.

Abstract

Male-specific reproductive disorders and cancers have increased intensely in recent years, making them a significant public health problem. Prostate cancer (PC) is the most often diagnosed cancer in men and is one of the leading causes of cancer-related mortality. Both genetic and epigenetic modifications contribute to the development and progression of PC, even though the exact underlying processes causing this disease have yet to be identified. Male infertility is also a complex and poorly understood phenomenon believed to afflict a significant portion of the male population. Chromosomal abnormalities, compromised DNA repair systems, and Y chromosome alterations are just a few of the proposed explanations. It is becoming widely accepted that infertility shares a link with PC. Much of the link between infertility and PC is probably attributable to common genetic defects. This article provides an overview of PC and spermatogenic abnormalities. This study also investigates the link between male infertility and PC and uncovers the underlying reasons, risk factors, and biological mechanisms contributing to this association.

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References

Honig S, Lipshultz L, Jarow J . Significant medical pathology uncovered by a comprehensive male infertility evaluation. Fertil Steril. 1994; 62(5):1028-34. View

Chen T, Belladelli F, Del Giudice F, Eisenberg M . Male fertility as a marker for health. Reprod Biomed Online. 2021; 44(1):131-144. DOI: 10.1016/j.rbmo.2021.09.023. View

Thoma M, McLain A, Louis J, King R, Trumble A, Sundaram R . Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil Steril. 2013; 99(5):1324-1331.e1. PMC: 3615032. DOI: 10.1016/j.fertnstert.2012.11.037. View

Murshidi M, Choy J, Eisenberg M . Male Infertility and Somatic Health. Urol Clin North Am. 2020; 47(2):211-217. DOI: 10.1016/j.ucl.2019.12.008. View

Levine H, Jorgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I . Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017; 23(6):646-659. PMC: 6455044. DOI: 10.1093/humupd/dmx022. View

Eisenberg M, Li S, Cullen M, Baker L . Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data. Fertil Steril. 2015; 105(3):629-636. DOI: 10.1016/j.fertnstert.2015.11.011. View

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

Massenkeil G, Oberhuber H, Hailemariam S, Sulser T, Diener P, Bannwart F . P53 mutations and loss of heterozygosity on chromosomes 8p, 16q, 17p, and 18q are confined to advanced prostate cancer. Anticancer Res. 1994; 14(6B):2785-90. View

Phin S, Moore M, Cotter P . Genomic Rearrangements of PTEN in Prostate Cancer. Front Oncol. 2013; 3:240. PMC: 3775430. DOI: 10.3389/fonc.2013.00240. View

10.

Tomlins S, Rhodes D, Perner S, Dhanasekaran S, Mehra R, Sun X . Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005; 310(5748):644-8. DOI: 10.1126/science.1117679. View

11.

Boysen G, Barbieri C, Prandi D, Blattner M, Chae S, Dahija A . SPOP mutation leads to genomic instability in prostate cancer. Elife. 2015; 4. PMC: 4621745. DOI: 10.7554/eLife.09207. View

12.

Liao Y, Xu K . Epigenetic regulation of prostate cancer: the theories and the clinical implications. Asian J Androl. 2018; 21(3):279-290. PMC: 6498736. DOI: 10.4103/aja.aja_53_18. View

13.

Walsh T, Schembri M, Turek P, Chan J, Carroll P, Smith J . Increased risk of high-grade prostate cancer among infertile men. Cancer. 2010; 116(9):2140-7. PMC: 2893877. DOI: 10.1002/cncr.25075. View

14.

Eisenberg M, Li S, Behr B, Reijo Pera R, Cullen M . Relationship between semen production and medical comorbidity. Fertil Steril. 2014; 103(1):66-71. DOI: 10.1016/j.fertnstert.2014.10.017. View

15.

Hanson H, Anderson R, Aston K, Carrell D, Smith K, Hotaling J . Subfertility increases risk of testicular cancer: evidence from population-based semen samples. Fertil Steril. 2015; 105(2):322-8.e1. PMC: 4744156. DOI: 10.1016/j.fertnstert.2015.10.027. View

16.

Ruhayel Y, Giwercman A, Ulmert D, Rylander L, Bjartell A, Manjer J . Male infertility and prostate cancer risk: a nested case-control study. Cancer Causes Control. 2010; 21(10):1635-43. DOI: 10.1007/s10552-010-9592-8. View

17.

Giwercman A, Richiardi L, Kaijser M, Ekbom A, Akre O . Reduced risk of prostate cancer in men who are childless as compared to those who have fathered a child: a population based case-control study. Int J Cancer. 2005; 115(6):994-7. DOI: 10.1002/ijc.20963. View

18.

Jorgensen K, Pedersen B, Johansen C, Frisch M . Fatherhood status and prostate cancer risk. Cancer. 2008; 112(4):919-23. DOI: 10.1002/cncr.23230. View

19.

Wiren S, Drevin L, Carlsson S, Akre O, Holmberg E, Robinson D . Fatherhood status and risk of prostate cancer: nationwide, population-based case-control study. Int J Cancer. 2013; 133(4):937-43. PMC: 3734704. DOI: 10.1002/ijc.28057. View

20.

Eisenberg M, Park Y, Brinton L, Hollenbeck A, Schatzkin A . Fatherhood and incident prostate cancer in a prospective US cohort. Int J Epidemiol. 2010; 40(2):480-7. PMC: 3066425. DOI: 10.1093/ije/dyq163. View