Research Diagnostic Criteria for Mild Cognitive Impairment with Lewy Bodies: A Systematic Review and Meta-analysis

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2023 Apr 25

PMID 37096339

Authors

Paul C Donaghy

Claudia Carrarini

Daniel Ferreira

Annegret Habich

Dag Aarsland

Claudio Babiloni

Ece Bayram

Joseph Pm Kane

Simon Jg Lewis

Andrea Pilotto

Alan J Thomas

Laura Bonanni

Affiliations

Soon will be listed here.

Abstract

Introduction: Operationalized research criteria for mild cognitive impairment with Lewy bodies (MCI-LB) were published in 2020. The aim of this systematic review and meta-analysis was to review the evidence for the diagnostic clinical features and biomarkers in MCI-LB set out in the criteria.

Methods: MEDLINE, PubMed, and Embase were searched on 9/28/22 for relevant articles. Articles were included if they presented original data reporting the rates of diagnostic features in MCI-LB.

Results: Fifty-seven articles were included. The meta-analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and meta-iodobenzylguanidine cardiac scintigraphy, though limited, supports their inclusion. Quantitative electroencephalogram (EEG) and fluorodeoxyglucose positron emission tomography (PET) show promise as diagnostic biomarkers.

Discussion: The available evidence largely supports the current diagnostic criteria for MCI-LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research.

Highlights: A meta-analysis of the diagnostic features of MCI-LB was carried out. The four core clinical features were more common in MCI-LB than MCI-AD/stable MCI. Neuropsychiatric and autonomic features were also more common in MCI-LB. More evidence is needed for the proposed biomarkers. FDG-PET and quantitative EEG show promise as diagnostic biomarkers in MCI-LB.

Citing Articles

Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum.

Ferreira D, Przybelski S, Lesnick T, Diaz-Galvan P, Schwarz C, Murray M JAMA Neurol. 2025; 82(3):285-294.

PMID: 39804619 PMC: 11894489. DOI: 10.1001/jamaneurol.2024.4643.

Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.

Wyman-Chick K, Bayram E, Gravett S, DAntonio F, Rodriguez-Porcel F, Kane J Alzheimers Dement. 2025; 21(2):e14450.

PMID: 39791487 PMC: 11848198. DOI: 10.1002/alz.14450.

The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies.

Wyman-Chick K, Barrett M, Miller M, Sargent L, Chrenka E, Kane J Alzheimers Dement (Amst). 2024; 16(4):e70034.

PMID: 39677584 PMC: 11645712. DOI: 10.1002/dad2.70034.

Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.

Zeleznikova Z, Novakova L, Vojtisek L, Brabenec L, Mitterova K, Moravkova I Mov Disord. 2024; 40(2):276-284.

PMID: 39535454 PMC: 11832806. DOI: 10.1002/mds.30058.

Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses.

Mantovani E, Martini A, Dinoto A, Zucchella C, Ferrari S, Mariotto S NPJ Parkinsons Dis. 2024; 10(1):211.

PMID: 39488513 PMC: 11531557. DOI: 10.1038/s41531-024-00823-x.

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