Plasmonic Sensing Assay for Long-Term Monitoring (PSALM) of Neurotransmitters in Urine

Overview

Journal ACS Nanosci Au

Publisher American Chemical Society

Specialty Biotechnology

Date 2023 Apr 25

PMID 37096231

Authors

Wei-Hsin Chen

Wenting Wang

Qianqi Lin

David-Benjamin Grys

Marika Niihori

Junyang Huang

Shu Hu

Bart de Nijs

Oren A Scherman

Jeremy J Baumberg

Affiliations

Soon will be listed here.

Abstract

A liquid-based surface-enhanced Raman spectroscopy assay termed PSALM is developed for the selective sensing of neurotransmitters (NTs) with a limit of detection below the physiological range of NT concentrations in urine. This assay is formed by quick and simple nanoparticle (NP) "mix-and-measure" protocols, in which Fe bridges NTs and gold NPs inside the sensing hotspots. Detection limits of NTs from PSALM are significantly lower than those of PSALM, when urine is pretreated by affinity separation. Optimized PSALM enables the long-term monitoring of NT variation in urine in conventional settings for the first time, allowing the development of NTs as predictive or correlative biomarkers for clinical diagnosis.

Citing Articles

In situ electrochemical regeneration of nanogap hotspots for continuously reusable ultrathin SERS sensors.

Sibug-Torres S, Grys D, Kang G, Niihori M, Wyatt E, Spiesshofer N Nat Commun. 2024; 15(1):2022.

PMID: 38448412 PMC: 10917746. DOI: 10.1038/s41467-024-46097-y.

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry.

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