Report of Natural Mayaro Virus Infection in Mansonia Humeralis (Dyar & Knab, Diptera: Culicidae)

Overview

Journal Parasit Vectors

Publisher Biomed Central

Specialties Parasitology
Tropical Medicine

Date 2023 Apr 24

PMID 37095528

Authors

Flavia Barreto de Sousa

Juliana Santana de Curcio

Livia do Carmo Silva

Diego Michel Fernandes Da Silva

Silvia Maria Salem-Izacc

Carlos Eduardo Anunciacao

Bergmann Morais Ribeiro

Marco Tulio A Garcia-Zapata

Elisangela de Paula Silveira-Lacerda

Affiliations

Soon will be listed here.

Abstract

Background: Arboviruses are a group of viruses transmitted to vertebrate hosts by certain blood-feeding arthropods. Among urban vectors of arboviruses, mosquitoes of the genus Aedes are the most common. However, other mosquitoes may be susceptible to infection and involved in the transmission, such as Mansonia spp. Therefore, this study aimed to investigate whether Mansonia humeralis can be infected with the Mayaro virus (MAYV).

Methods: These insects were collected from 2018 to 2020 in chicken coops of rural communities in Jaci Paraná in Porto Velho, Rondônia, Brazil, while performing blood-feeding on roosters. The mosquitoes were randomly grouped in pools from which the head and thorax were macerated and checked for the presence of MAYV by quantitative reverse transcription polymerase chain reaction (RT-qPCR). The positive pools were used to infect the C6/36 cell line, and on different days post-infection, the supernatant of the infected cells was subjected to viral detection by RT-qPCR.

Results: A total of 183 pools of female mosquitoes were tested, of which 18% were positive for MAYV; some samples from insect pools inoculated into C6/36 cells showed in vitro multiplication capacity between 3 and 7 days post-infection.

Conclusions: This is the first report of Ma. humeralis mosquitoes that are naturally infected by MAYV, indicating that these vectors may be potential transmitting agents of this arbovirus.

Citing Articles

Trends of Mansonia (Diptera, Culicidae, Mansoniini) in Porto Velho: Seasonal patterns and meteorological influences.

Saraiva J, Furtado N, Maitra A, Carvalho D, Galardo A, Lima J PLoS One. 2024; 19(5):e0303405.

PMID: 38718006 PMC: 11078429. DOI: 10.1371/journal.pone.0303405.

Detection of arboviruses in Aedes aegypti through transovarian analysis: A study in Goiânia, Goiás.

Silva D, Santana de Curcio J, do Carmo Silva L, Sousa F, Anunciacao C, Furlaneto S Rev Soc Bras Med Trop. 2024; 57:e004002023.

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Identification of Mayaro Virus Genotype D in Rondônia, Brazil.

Pimentel E, Queiroz J, Ribeiro J, Moreira H, Passos-Silva A, Oliveira A Am J Trop Med Hyg. 2024; 110(3):557-560.

PMID: 38295410 PMC: 10919187. DOI: 10.4269/ajtmh.23-0535.

Bacterial diversity on larval and female Mansonia spp. from different localities of Porto Velho, Rondonia, Brazil.

Oliveira T, Rojas M, Amorim J, Alonso D, de Carvalho D, Ribeiro K PLoS One. 2023; 18(11):e0293946.

PMID: 38011160 PMC: 10681206. DOI: 10.1371/journal.pone.0293946.

Bioecological Aspects of Species of the Subgenus () (Diptera: Culicidae) Prior to the Installation of Hydroelectric Dams on the Madeira River, Rondônia State, Brazil.

Ferreira F, Costa F, Gouveia A, Roque R, Tadei W, Scarpassa V Trop Med Infect Dis. 2023; 8(10).

PMID: 37888607 PMC: 10610653. DOI: 10.3390/tropicalmed8100479.

References

Lai Z, Zhou T, Zhou J, Liu S, Xu Y, Gu J . Vertical transmission of zika virus in Aedes albopictus. PLoS Negl Trop Dis. 2020; 14(10):e0008776. PMC: 7671534. DOI: 10.1371/journal.pntd.0008776. View

Maia L, Bezerra M, Costa M, Souza E, Oliveira M, Ribeiro A . Natural vertical infection by dengue virus serotype 4, Zika virus and Mayaro virus in Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus. Med Vet Entomol. 2019; 33(3):437-442. DOI: 10.1111/mve.12369. View

Wu P, Yu X, Wang P, Cheng G . Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Rev Mol Med. 2019; 21:e1. DOI: 10.1017/erm.2018.6. View

Jeger M, Madden L, van den Bosch F . The effect of transmission route on plant virus epidemic development and disease control. J Theor Biol. 2009; 258(2):198-207. DOI: 10.1016/j.jtbi.2009.01.012. View

Moyes C, Vontas J, Martins A, Ng L, Koou S, Dusfour I . Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans. PLoS Negl Trop Dis. 2017; 11(7):e0005625. PMC: 5518996. DOI: 10.1371/journal.pntd.0005625. View

AITKEN T, Anderson C . Virus transmission studies with Trinidadian mosquitoes II. Further observations. Am J Trop Med Hyg. 1959; 8(1):41-5. DOI: 10.4269/ajtmh.1959.8.41. View

Morales-Betoulle M, Komar N, Panella N, Alvarez D, Lopez M, Betoulle J . West Nile virus ecology in a tropical ecosystem in Guatemala. Am J Trop Med Hyg. 2012; 88(1):116-26. PMC: 3541721. DOI: 10.4269/ajtmh.2012.12-0276. View

Hoch A, Peterson N, LeDuc J, Pinheiro F . An outbreak of Mayaro virus disease in Belterra, Brazil. III. Entomological and ecological studies. Am J Trop Med Hyg. 1981; 30(3):689-98. DOI: 10.4269/ajtmh.1981.30.689. View

Ferreira R, de Toni Aquino da Cruz L, de Souza V, da Silva Neves N, de Souza V, Franco Filho L . Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil. Infect Genet Evol. 2020; 85:104561. DOI: 10.1016/j.meegid.2020.104561. View

10.

Mello C, Alencar J . Dispersion pattern of Mansonia in the surroundings of the Amazon Jirau Hydroelectric Power Plant. Sci Rep. 2021; 11(1):24273. PMC: 8688500. DOI: 10.1038/s41598-021-03682-1. View

11.

Marinho R, Duro R, Caldeira D, Galinskas J, Oliveira Mota M, Hunter J . Re-emergence of mayaro virus and coinfection with chikungunya during an outbreak in the state of Tocantins/Brazil. BMC Res Notes. 2022; 15(1):271. PMC: 9351195. DOI: 10.1186/s13104-022-06153-6. View

12.

Gubler D . Human arbovirus infections worldwide. Ann N Y Acad Sci. 2002; 951:13-24. DOI: 10.1111/j.1749-6632.2001.tb02681.x. View

13.

Long K, Ziegler S, Thangamani S, Hausser N, Kochel T, Higgs S . Experimental transmission of Mayaro virus by Aedes aegypti. Am J Trop Med Hyg. 2011; 85(4):750-7. PMC: 3183788. DOI: 10.4269/ajtmh.2011.11-0359. View

14.

Tallman P, Riley-Powell A, Schwarz L, Salmon-Mulanovich G, Southgate T, Pace C . Ecosyndemics: The potential synergistic health impacts of highways and dams in the Amazon. Soc Sci Med. 2020; 295:113037. DOI: 10.1016/j.socscimed.2020.113037. View

15.

Diallo D, Sall A, Buenemann M, Chen R, Faye O, Diagne C . Landscape ecology of sylvatic chikungunya virus and mosquito vectors in southeastern Senegal. PLoS Negl Trop Dis. 2012; 6(6):e1649. PMC: 3373654. DOI: 10.1371/journal.pntd.0001649. View

16.

Galindo P, SRIHONGSE S, DE RODANICHE E, Grayson M . An ecological survey for arboviruses in Almirante, Panama, 1959-1962. Am J Trop Med Hyg. 1966; 15(3):385-400. DOI: 10.4269/ajtmh.1966.15.385. View

17.

Kading R, Reiche A, Morales-Betoulle M, Komar N . Host selection of potential West Nile virus vectors in Puerto Barrios, Guatemala, 2007. Am J Trop Med Hyg. 2012; 88(1):108-15. PMC: 3541720. DOI: 10.4269/ajtmh.2012.12-0223. View

18.

Santana de Curcio J, Salem-Izacc S, Pereira Neto L, Nunes E, Anunciacao C, Silveira-Lacerda E . Detection of Mayaro virus in Aedes aegypti mosquitoes circulating in Goiânia-Goiás-Brazil. Microbes Infect. 2022; 24(4):104948. DOI: 10.1016/j.micinf.2022.104948. View

19.

Acosta-Ampudia Y, Monsalve D, Rodriguez Y, Pacheco Y, Anaya J, Ramirez-Santana C . Mayaro: an emerging viral threat?. Emerg Microbes Infect. 2018; 7(1):163. PMC: 6156602. DOI: 10.1038/s41426-018-0163-5. View

20.

Galindo P, SRIHONGSE S . Transmission of arboviruses to hamsters by the bite of naturally infected Culex (Melanoconion) mosquitoes. Am J Trop Med Hyg. 1967; 16(4):525-30. DOI: 10.4269/ajtmh.1967.16.525. View