Application Effect of an Artificial Intelligence-based Fundus Screening System: Evaluation in a Clinical Setting and Population Screening

Overview

Journal Biomed Eng Online

Publisher Biomed Central

Specialty Biomedical Engineering

Date 2023 Apr 24

PMID 37095516

Authors

Shujuan Cao

Rongpei Zhang

Aixin Jiang

Mayila Kuerban

Aizezi Wumaier

Jianhua Wu

Kaihua Xie

Mireayi Aizezi

Abudurexiti Tuersun

Xuanwei Liang

Rongxin Chen

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the application effect of artificial intelligence (AI)-based fundus screening system in real-world clinical environment.

Methods: A total of 637 color fundus images were included in the analysis of the application of the AI-based fundus screening system in the clinical environment and 20,355 images were analyzed in the population screening.

Results: The AI-based fundus screening system demonstrated superior diagnostic effectiveness for diabetic retinopathy (DR), retinal vein occlusion (RVO) and pathological myopia (PM) according to gold standard referral. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of three fundus abnormalities were greater (all > 80%) than those for age-related macular degeneration (ARMD), referable glaucoma and other abnormalities. The percentages of different diagnostic conditions were similar in both the clinical environment and the population screening.

Conclusions: In a real-world setting, our AI-based fundus screening system could detect 7 conditions, with better performance for DR, RVO and PM. Testing in the clinical environment and through population screening demonstrated the clinical utility of our AI-based fundus screening system in the early detection of ocular fundus abnormalities and the prevention of blindness.

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