Diagnosis and Severity Criteria for Sinusoidal Obstruction Syndrome/veno-occlusive Disease in Adult Patients: a Refined Classification from the European Society for Blood and Marrow Transplantation (EBMT)

Overview

Journal Bone Marrow Transplant

Specialty General Surgery

Date 2023 Apr 24

PMID 37095231

Authors

Mohamad Mohty

Florent Malard

Ahmed S Alaskar

Mahmoud Aljurf

Mutlu Arat

Peter Bader

Frederic Baron

Ali Bazarbachi

Didier Blaise

Eolia Brissot

Fabio Ciceri

Selim Corbacioglu

Jean-Hugues Dalle

Fiona Dignan

Anne Huynh

Michelle Kenyon

Arnon Nagler

Antonio Pagliuca

Zinaida Peric

Paul G Richardson

Annalisa Ruggeri

Tapani Ruutu

Ibrahim Yakoub-Agha

Rafael F Duarte

Enric Carreras

Affiliations

Soon will be listed here.

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.

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