Angiopoietin-2-Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 Apr 24

PMID 37093870

Authors

Ha-Ram Park

Anahita Shiva

Portia Cummings

Seoyeon Kim

Sungsoo Kim

Eunhyeong Lee

Alessandra Leong

Subrata Chowdhury

Carrie Shawber

Richard Carvajal

Gavin Thurston

Joon-Yong An

Amanda W Lund

Hee Won Yang

Minah Kim

Affiliations

Soon will be listed here.

Abstract

Significance: ANGPT2 limits the efficacy of immunotherapy by inducing vascular destabilization at the tumor periphery to promote T-cell exclusion.

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