Computational Modeling of the Human Compound Action Potential

Overview

Journal J Acoust Soc Am

Publisher American Institute of Physics

Specialty Otorhinolaryngology

Date 2023 Apr 24

PMID 37092943

Authors

Yousef Alamri

Skyler G Jennings

Affiliations

Soon will be listed here.

Abstract

The auditory nerve (AN) compound action potential (CAP) is an important tool for assessing auditory disorders and monitoring the health of the auditory periphery during surgical procedures. The CAP has been mathematically conceptualized as the convolution of a unit response (UR) waveform with the firing rate of a population of AN fibers. Here, an approach for predicting experimentally recorded CAPs in humans is proposed, which involves the use of human-based computational models to simulate AN activity. CAPs elicited by clicks, chirps, and amplitude-modulated carriers were simulated and compared with empirically recorded CAPs from human subjects. In addition, narrowband CAPs derived from noise-masked clicks and tone bursts were simulated. Many morphological, temporal, and spectral aspects of human CAPs were captured by the simulations for all stimuli tested. These findings support the use of model simulations of the human CAP to refine existing human-based models of the auditory periphery, aid in the design and analysis of auditory experiments, and predict the effects of hearing loss, synaptopathy, and other auditory disorders on the human CAP.

Citing Articles

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Jennings S, Chen J, Johansen N, Goodman S J Assoc Res Otolaryngol. 2025; .

PMID: 40048123 DOI: 10.1007/s10162-025-00979-0.

Estimation of Cochlear Frequency Selectivity Using a Convolution Model of Forward-Masked Compound Action Potentials.

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PMID: 38278969 PMC: 10907335. DOI: 10.1007/s10162-023-00922-1.

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