IL-1 and Allergy: Focusing on Its Role in Allergic Rhinitis

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2023 Apr 24

PMID 37091903

Authors

Han-Rui Wang

Shi-Zhuang Wei

Xiao-Yu Song

Yao Wang

Wen-Bin Zhang

Chao Ren

Ya-Kui Mou

Xi-Cheng Song

Affiliations

Soon will be listed here.

Abstract

Allergic rhinitis (AR) is a chronic upper airway immune-inflammation response mediated by immunoglobulin E (IgE) to allergens and can seriously affect the quality of life and work efficiency. Previous studies have shown that interleukin-1 (IL-1) acts as a key cytokine to participate in and promote the occurrence and development of allergic diseases. It has been proposed that IL-1 may be a potential biomarker of AR. However, its definitive role and potential mechanism in AR have not been fully elucidated, and the clinical sample collection and detection methods were inconsistent among different studies, which have limited the use of IL-1 as a clinical diagnosis and treatment marker for AR. This article systematically summarizes the research advances in the roles of IL-1 in allergic diseases, focusing on the changes of IL-1 in AR and the possible interventions. In addition, based on the findings by our team, we provided new insights into the use of IL-1 in AR diagnosis and treatment, in an attempt to further promote the clinical application of IL-1 in AR and other allergic diseases.

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References

Goldbach-Mansky R, Dailey N, Canna S, Gelabert A, Jones J, Rubin B . Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med. 2006; 355(6):581-92. PMC: 4178954. DOI: 10.1056/NEJMoa055137. View

Qian X, Aboushousha R, van de Wetering C, Chia S, Amiel E, Schneider R . IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease. J Allergy Clin Immunol. 2017; 142(2):435-450.e10. PMC: 6278819. DOI: 10.1016/j.jaci.2017.08.043. View

Arend W, Malyak M, Guthridge C, Gabay C . Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998; 16:27-55. DOI: 10.1146/annurev.immunol.16.1.27. View

Leszczynska K, Jakubczyk D, Gorska S . The NLRP3 inflammasome as a new target in respiratory disorders treatment. Front Immunol. 2022; 13:1006654. PMC: 9531678. DOI: 10.3389/fimmu.2022.1006654. View

Ruscitti P, Berardicurti O, Cipriani P, Giacomelli R . Benefits of anakinra versus TNF inhibitors in rheumatoid arthritis and type 2 diabetes: long-term findings from participants furtherly followed-up in the TRACK study, a multicentre, open-label, randomised, controlled trial. Clin Exp Rheumatol. 2021; 39(2):403-406. View

Weber F, Esser P, Muller T, Ganesan J, Pellegatti P, Simon M . Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med. 2010; 207(12):2609-19. PMC: 2989767. DOI: 10.1084/jem.20092489. View

Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M . IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol. 2003; 15(4):483-90. DOI: 10.1093/intimm/dxg054. View

Groves R, Mizutani H, Kieffer J, Kupper T . Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci U S A. 1995; 92(25):11874-8. PMC: 40505. DOI: 10.1073/pnas.92.25.11874. View

Ge X, Cai F, Shang Y, Chi F, Xiao H, Xu J . PARK2 attenuates house dust mite-induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS-2B cells by ubiquitinating NLRP3. Am J Transl Res. 2021; 13(1):326-335. PMC: 7847526. View

10.

Hudock K, Liu Y, Mei J, Marino R, Hale J, Dai N . Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. Am J Respir Cell Mol Biol. 2012; 47(4):436-44. PMC: 3488622. DOI: 10.1165/rcmb.2012-0104OC. View

11.

Shen Y, Ke X, Yun L, Hu G, Kang H, Hong S . Decreased expression of interleukin‑37 and its anti‑inflammatory effect in allergic rhinitis. Mol Med Rep. 2017; 17(1):1333-1339. DOI: 10.3892/mmr.2017.7988. View

12.

Chawes B, Wolsk H, Carlsson C, Rasmussen M, Folsgaard N, Stokholm J . Neonatal airway immune profiles and asthma and allergy endpoints in childhood. Allergy. 2021; 76(12):3713-3722. DOI: 10.1111/all.14862. View

13.

Kim K, Nam S, Shin T, Park K, Jeong H, Kim H . Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model. Food Chem Toxicol. 2012; 50(10):3480-8. DOI: 10.1016/j.fct.2012.07.017. View

14.

Lin H, Zheng C, Li J, Yang C, Hu L . Ca2+ -activated K+ channel-3.1 blocker TRAM-34 alleviates murine allergic rhinitis. Int Immunopharmacol. 2014; 23(2):642-8. DOI: 10.1016/j.intimp.2014.10.017. View

15.

Takizawa R, Pawankar R, Yamagishi S, Takenaka H, Yagi T . Increased expression of HLA-DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up-regulation by diesel exhaust particles. Clin Exp Allergy. 2007; 37(3):420-33. PMC: 7164828. DOI: 10.1111/j.1365-2222.2007.02672.x. View

16.

Zhao Z, Liang M, He H, Wang X, Zhu C, Li L . Ovalbumin-Induced Allergic Inflammation Diminishes Cross-Linked Collagen Structures in an Experimental Rabbit Model of Corneal Cross-Linking. Front Med (Lausanne). 2022; 9:762730. PMC: 9178108. DOI: 10.3389/fmed.2022.762730. View

17.

Zanoni I, Tan Y, Gioia M, Broggi A, Ruan J, Shi J . An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016; 352(6290):1232-6. PMC: 5111085. DOI: 10.1126/science.aaf3036. View

18.

Shiue H, Lee Y, Tsai C, Hsueh Y, Sheu J, Chang H . DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. J Altern Complement Med. 2008; 14(6):689-98. DOI: 10.1089/acm.2007.0669. View

19.

Wan H, Su H, Wu Y, Zhao Y, Zhou M . [Expression and significance of NLRP3 inflammasome and its downstream factors IL-1β/IL-18 in rat model of allergic rhinitis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015; 50(2):145-50. View

20.

Ma L, Zheng Y, Wang J, Li Q, Zeng J, Wang Z . Development of MIF/IL-1β biosensors for discovery of critical quality attributes and potential allergic rhinitis targets from clinical real-world data by intelligent algorithm coupled with in vitro and vivo mechanism validation. Biosens Bioelectron. 2021; 194:113608. DOI: 10.1016/j.bios.2021.113608. View