Association Between Serum Cys C and PTB Cavitation

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2023 Apr 24

PMID 37091891

Authors

Shumin Tan

Duochi Wu

Yeying Wu

Xing Ren

Jiaxiu Liu

Xiaobin Wei

Affiliations

Soon will be listed here.

Abstract

Background: Cystatin C (Cys C) not only regulates the body's immune defenses but also contributes to tissue degradation and destruction by causing an imbalance between protease and antiprotease in infectious diseases. Is Cys C involved in pulmonary tuberculosis (PTB) infection and cavitation? We therefore conducted a retrospective study on this question to provide a basis for further studies.

Methods: Cavitary PTB patients, noncavitary PTB patients, and healthy controls were recruited in our study. Serum Cys C, CRP, BUN, UA, and CR were measured in all subjects, and the Kruskal-Wallis test was used to compare medians of these clinical parameters in different groups. The Spearman rank correlation test was used to determine correlations between variables. In addition, a multivariate analysis using binary logistic regression was used to identify factors associated with PTB cavitation.

Results: In our study, elevated serum Cys C levels were found in cavitary PTB patients compared to healthy controls and noncavitary patients ( = 0.022). Serum Cys C levels were statistically correlated with serum BUN and CR concentrations ( = 0.278, = 0.005; = 0.281, = 0.004) in PTB patients. The binary logistic regression analysis showed that elevated serum Cys C levels were correlated with pulmonary cavitation in PTB patients (OR = 1.426, 95% CI: 1.071-1.898).

Conclusion: Elevated serum levels of Cys C are associated with pulmonary cavitation in PTB patients.

References

Sabir N, Hussain T, Mangi M, Zhao D, Zhou X . Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis. Cell Prolif. 2019; 52(4):e12649. PMC: 6668971. DOI: 10.1111/cpr.12649. View

Onopiuk A, Tokarzewicz A, Gorodkiewicz E . Cystatin C: a kidney function biomarker. Adv Clin Chem. 2015; 68:57-69. DOI: 10.1016/bs.acc.2014.11.007. View

Yu G, Sun X, Li L, Huang L, Liu H, Wang S . Cystatin C promotes cognitive dysfunction in rats with cerebral microbleeds by inhibiting the ERK/synapsin Ia/Ib pathway. Exp Ther Med. 2020; 19(3):2282-2290. PMC: 7027318. DOI: 10.3892/etm.2019.8403. View

Telo S, Kuluozturk M, Deveci F, Kirkil G, Oner O, Kaman D . Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation between Respiratory Functions. J Med Biochem. 2018; 37(4):434-440. PMC: 6298476. DOI: 10.1515/jomb-2017-0064. View

Rokadia H, Agarwal S . Serum cystatin C and emphysema: results from the National Health and Nutrition Examination Survey (NHANES). Lung. 2012; 190(3):283-90. DOI: 10.1007/s00408-012-9374-z. View

Saeed W . Cavitating pulmonary tuberculosis: a global challenge. Clin Med (Lond). 2012; 12(1):40-1. PMC: 4953415. DOI: 10.7861/clinmedicine.12-1-40. View

Helke K, Mankowski J, Manabe Y . Animal models of cavitation in pulmonary tuberculosis. Tuberculosis (Edinb). 2005; 86(5):337-48. DOI: 10.1016/j.tube.2005.09.001. View

Kubler A, Luna B, Larsson C, Ammerman N, Andrade B, Orandle M . Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2014; 235(3):431-44. PMC: 4293239. DOI: 10.1002/path.4432. View

Bjorck L, Akesson P, Bohus M, Trojnar J, Abrahamson M, Olafsson I . Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Nature. 1989; 337(6205):385-6. DOI: 10.1038/337385a0. View

10.

Bjorck L . Proteinase inhibition, immunoglobulin-binding proteins and a novel antimicrobial principle. Mol Microbiol. 1990; 4(9):1439-42. DOI: 10.1111/j.1365-2958.1990.tb02054.x. View

11.

Ong C, Elkington P, Friedland J . Tuberculosis, pulmonary cavitation, and matrix metalloproteinases. Am J Respir Crit Care Med. 2014; 190(1):9-18. PMC: 4226026. DOI: 10.1164/rccm.201311-2106PP. View

12.

Mauss S, Berger F, Kuschak D, Henke J, Hegener P, Wolf E . Cystatin C as a marker of renal function is affected by HIV replication leading to an underestimation of kidney function in HIV patients. Antivir Ther. 2009; 13(8):1091-5. View

13.

Pires D, Bernard E, Pombo J, Carmo N, Fialho C, Gutierrez M . Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation. Front Immunol. 2018; 8:1819. PMC: 5741618. DOI: 10.3389/fimmu.2017.01819. View

14.

Long Q, Guo L, Jiang W, Huan S, Tang S . Ending tuberculosis in China: health system challenges. Lancet Public Health. 2021; 6(12):e948-e953. DOI: 10.1016/S2468-2667(21)00203-6. View

15.

Angelidis C, Deftereos S, Giannopoulos G, Anatoliotakis N, Bouras G, Hatzis G . Cystatin C: an emerging biomarker in cardiovascular disease. Curr Top Med Chem. 2013; 13(2):164-79. DOI: 10.2174/1568026611313020006. View

16.

Blancas-Luciano B, Becker-Fauser I, Zamora-Chimal J, Delgado-Dominguez J, Ruiz-Remigio A, Leyva-Huerta E . Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with . PeerJ. 2022; 10:e14232. PMC: 9615962. DOI: 10.7717/peerj.14232. View

17.

Chakaya J, Khan M, Ntoumi F, Aklillu E, Fatima R, Mwaba P . Global Tuberculosis Report 2020 - Reflections on the Global TB burden, treatment and prevention efforts. Int J Infect Dis. 2021; 113 Suppl 1:S7-S12. PMC: 8433257. DOI: 10.1016/j.ijid.2021.02.107. View

18.

Xu Y, Ding Y, Li X, Wu X . Cystatin C is a disease-associated protein subject to multiple regulation. Immunol Cell Biol. 2015; 93(5):442-51. PMC: 7165929. DOI: 10.1038/icb.2014.121. View

19.

Zi M, Xu Y . Involvement of cystatin C in immunity and apoptosis. Immunol Lett. 2018; 196:80-90. PMC: 7112947. DOI: 10.1016/j.imlet.2018.01.006. View

20.

Wu X, Dong Z, Lu Q . The role of cystatin C in vascular remodeling of balloon-injured abdominal aorta of rabbits. Mol Biol Rep. 2014; 41(9):6225-31. DOI: 10.1007/s11033-014-3502-1. View