Abnormal Expression of MAPK14-related LncRNAs in the Peripheral Blood of Patients with Multiple Sclerosis

Overview

Journal Noncoding RNA Res

Date 2023 Apr 24

PMID 37091283

Authors

Soudeh Ghafouri-Fard

Mahdi Gholipour

Solat Eslami

Bashdar Mahmud Hussen

Mohammad Taheri

Mohammad Samadian

Mir Davood Omrani

Affiliations

Soon will be listed here.

Abstract

Introduction: Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14).

Methods: Expression levels of and its associated lncRNAs were measured in the circulation of MS patients compared with control subjects.

Results: Expression levels of and were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04-1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43-2.6), P value = 0.0001, respectively). Conversely, was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41-0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset.

Conclusion: To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients.

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