Predicting and Grading Liver Injury in the Absence of Computed Tomographic Imaging

Overview

Journal J Family Med Prim Care

Specialty Public Health

Date 2023 Apr 24

PMID 37091021

Authors

Mario Victor Newton

S G Subramanyam

Affiliations

Soon will be listed here.

Abstract

Background: Even developed countries lack computed tomography (CT) scan in rural areas. Availability, affordability and accessibility of CT scan play an important role in the management of blunt hepatic trauma.

Materials And Methods: A descriptive observational study among 56 hepatic blunt trauma patients as Group 1 and 56 non-hepatic blunt trauma patients as Group 2 enrolled retrospectively. Observational analysis of presence of liver trauma, grades of liver injury (I-VI) and clinical course with the liver function tests are done.

Results: Aspartate transaminase (AST) ( = 0.02) and alanine transaminase (ALT) ( = 0.003) levels were significantly elevated among Group 1. Significantly elevated levels in Group 1 than Group 2 of AST [467.5 (22-5097) vs. 95 (23-1780); < 0.001] and of ALT [422 (28-1548) vs. 69 (20-727); < 0.001] noted. Significant elevation of AST and ALT levels, as the AAST (American Association for the Surgery of Trauma) CT grade of liver injury increases, noted ( = 0.001). Using the ROC curve analysis, the optimal cut-off values of AST and ALT were set at ≥467.5 U/L and ≥111.5 U/L, respectively. At this cut-off, AST had sensitivity 50%, specificity 91.7%, PPV 85%, NPV 66%, ALT had sensitivity 85.3%, specificity 86.1%, PPV 85.3% and NPV 86.1% for liver injury.

Conclusion: ALT is more sensitive for liver injury. AST peak is seen in the immediate period. Combining clinical assessment, transaminase levels and Focused Assessment with Sonography in Trauma improves the sensitivity and specificity. Transaminase levels can vary with ethnicity and local epidemiological diseases; therefore, optimal cut-off levels should be established for local population. This would predict and grade the liver injury, helping in early decision-making and avoid wasting the golden hour in trauma.

Citing Articles

Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker.

Horauf J, Singh A, Voth M, Moheimani H, Schindler C, Relja B Diagnostics (Basel). 2025; 15(2).

PMID: 39857063 PMC: 11764008. DOI: 10.3390/diagnostics15020179.

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