Synthesis of N-heterocyclic Amides Based on (+)-camphoric Acid and Study of Their Antiviral Activity and Pharmacokinetics

Overview

Journal Russ Chem Bull

Date 2023 Apr 24

PMID 37089866

Authors

O I Yarovaya

D V Baranova

A S Sokolova

A G Nemolochnova

O P Salnikova

A V Fatanova

A D Rogachev

A S Volobueva

V V Zarubaev

A G Pokrovsky

N F Salakhutdinov

Affiliations

Soon will be listed here.

Abstract

Efficient conditions for the synthesis of nitrogen-containing heterocyclic derivatives of (1,3)(+)-camphoric acid were selected. A series of heterocyclic compounds based on (+)-camphoric acid bearing pharmacophoric fragments was synthesized using the developed methodology. The compounds were tested for their antiviral activity against SARS-CoV-2 and H1N1 influenza viruses, and efficient inhibitors were identified that are of significant interest for further studies. The stability of the compounds and pharmaco-kinetics of the leader compound were studied when administered intragastrically and intramuscularly to mice at a dose of 200 mg kg using the HPLC-MS/MS method.

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