Adipopenia in Body Composition Analysis: a Promising Imaging Biomarker and Potential Predictive Factor for Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2023 Apr 22

PMID 37086078

Authors

Georgios Luca Alatzides

Johannes Haubold

Hannah Luisa Steinberg

Sven Koitka

Vicky Parmar

Johannes Grueneisen

Amos Cornelius Zeller

Hartmut Schmidt

Jens Matthias Theysohn

Yan Li

Felix Nensa

Benedikt Michael Schaarschmidt

Affiliations

Soon will be listed here.

Abstract

Objective: Body tissue composition plays a crucial role in the multisystemic processes of advanced liver disease and has been shown to be influenced by transjugular intrahepatic portosystemic shunt (TIPS). A differentiated analysis of the various tissue compartments has not been performed until now. The purpose of this study was to evaluate the value of imaging biomarkers derived from automated body composition analysis (BCA) to predict clinical and functional outcome.

Methods: A retrospective analysis of 56 patients undergoing TIPS procedure between 2013 and 2021 was performed. BCA on the base of pre-interventional CT examination was used to determine quantitative data as well as ratios of bone, muscle and fat masses. Furthermore, a BCA-derived sarcopenia marker was investigated. Regarding potential correlations between BCA imaging biomarkers and the occurrence of hepatic encephalopathy (HE) as well as 1-year survival, an exploratory analysis was conducted.

Results: No BCA imaging biomarker was associated with the occurrence of HE after TIPS placement. However, there were significant differences in alive and deceased patients regarding the BCA-derived sarcopenia marker (alive: 1.60, deceased: 1.83, = 0.046), ratios of intra- and intermuscular fat/skeletal volume (alive: 0.53, deceased: 0.31, = 0.015) and intra- and intermuscular fat/muscle volume (alive: 0.21, deceased: 0.14, = 0.031).

Conclusion: A lower amount of intra- and intermuscular adipose tissue might have protective effects regarding liver derived complications and survival.

Advances In Knowledge: Precise characterization of body tissue components with automated BCA might provide prognostic information in patients with advanced liver disease undergoing TIPS procedure.

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