» Articles » PMID: 37085610

FLT3 Inhibitors Upregulate CXCR4 and E-selectin Ligands Via ERK Suppression in AML Cells and CXCR4/E-selectin Inhibition Enhances Anti-leukemia Efficacy of FLT3-targeted Therapy in AML

Citing Articles

Small Extracellular Vesicles from Breast Cancer Cells Induce Cardiotoxicity.

Osorio-Mendez J, Gomez-Grosso L, Montoya-Ortiz G, Novoa-Herran S, Dominguez-Romero Y Int J Mol Sci. 2025; 26(3).

PMID: 39940718 PMC: 11816698. DOI: 10.3390/ijms26030945.


Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia.

Boueya I, Sandhow L, Albuquerque J, Znaidi R, Passaro D Leukemia. 2024; 39(1):8-24.

PMID: 39528790 PMC: 11717709. DOI: 10.1038/s41375-024-02453-x.


Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis.

Zheng L, Pan C, Ma D, Shang Q, Hu T, Zhang T Front Pharmacol. 2024; 15:1393482.

PMID: 39081954 PMC: 11286583. DOI: 10.3389/fphar.2024.1393482.


Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?.

Uy G, DeAngelo D, Lozier J, Fisher D, Jonas B, Magnani J Blood Rev. 2024; 65:101184.

PMID: 38493006 PMC: 11051645. DOI: 10.1016/j.blre.2024.101184.


The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae.

Hemsing A, Forde J, Reikvam H, Herfindal L Transl Oncol. 2024; 40:101876.

PMID: 38185059 PMC: 10818244. DOI: 10.1016/j.tranon.2024.101876.


References
1.
Kottaridis P, Gale R, Linch D . Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia. Leuk Lymphoma. 2003; 44(6):905-13. DOI: 10.1080/1042819031000067503. View

2.
Kennedy V, Smith C . Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies. Front Oncol. 2021; 10:612880. PMC: 7787101. DOI: 10.3389/fonc.2020.612880. View

3.
Zhang W, Konopleva M, Shi Y, McQueen T, Harris D, Ling X . Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst. 2008; 100(3):184-98. DOI: 10.1093/jnci/djm328. View

4.
Tabe Y, Konopleva M . Role of Microenvironment in Resistance to Therapy in AML. Curr Hematol Malig Rep. 2015; 10(2):96-103. PMC: 4447522. DOI: 10.1007/s11899-015-0253-6. View

5.
Lapidot T, Dar A, Kollet O . How do stem cells find their way home?. Blood. 2005; 106(6):1901-10. DOI: 10.1182/blood-2005-04-1417. View