State-of-the-art Review and Update of Models of Necrotizing Enterocolitis

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2023 Apr 21

PMID 37082706

Authors

Geoanna M Bautista

Anjali J Cera

Hala Chaaban

Steven J McElroy

Affiliations

Soon will be listed here.

Abstract

NEC remains one of the most common causes of mortality and morbidity in preterm infants. Animal models of necrotizing enterocolitis (NEC) have been crucial in improving our understanding of this devastating disease and identifying biochemical pathways with therapeutic potential. The pathogenesis of NEC remains incompletely understood, with no specific entity that unifies all infants that develop NEC. Therefore, investigators rely on animal models to manipulate variables and provide a means to test interventions, making them valuable tools to enhance our understanding and prevent and treat NEC. The advancements in molecular analytic tools, genetic manipulation, and imaging modalities and the emergence of scientific collaborations have given rise to unique perspectives and disease correlates, creating novel pathways of investigation. A critical review and understanding of the current phenotypic considerations of the highly relevant animal models of NEC are crucial to developing novel therapeutic and preventative strategies for NEC.

Citing Articles

Redox Chemistry: Implications for Necrotizing Enterocolitis.

Gershner G, Hunter C Int J Mol Sci. 2024; 25(15).

PMID: 39125983 PMC: 11312856. DOI: 10.3390/ijms25158416.

Immunological aspects of necrotizing enterocolitis models: a review.

Blum L, Vincent D, Boettcher M, Knopf J Front Immunol. 2024; 15:1434281.

PMID: 39104529 PMC: 11298363. DOI: 10.3389/fimmu.2024.1434281.

Nursing practice of routine gastric aspiration in preterm infants and its link to necrotizing enterocolitis: is the practice still clinically relevant?.

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Antenatal Infection Causes Colonic Mucus Barrier Defects: Implications for Intestinal Pathologies.

van Gorp C, de Lange I, Hutten M, Lopez-Iglesias C, Massy K, Kessels L Int J Mol Sci. 2024; 25(7).

PMID: 38612809 PMC: 11011967. DOI: 10.3390/ijms25074000.

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