Runt-related Transcription Factors in Human Carcinogenesis: a Friend or Foe?

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2023 Apr 20

PMID 37081242

Authors

Adhiraj Roy

Shivi Chauhan

Sujata Bhattacharya

Vibhuti Jakhmola

Komal Tyagi

Abha Sachdeva

Abdul Wasai

Supratim Mandal

Affiliations

Soon will be listed here.

Abstract

Purpose: Cancer is one of the deadliest pathologies with more than 19 million new cases and 10 million cancer-related deaths across the globe. Despite development of advanced therapeutic interventions, cancer remains as a fatal pathology due to lack of early prognostic biomarkers, therapy resistance and requires identification of novel drug targets.

Methods: Runt-related transcription factors (Runx) family controls several cellular and physiological functions including osteogenesis. Recent literatures from PubMed was mined and the review was written in comprehensive manner RESULTS: Recent literature suggests that aberrant expression of Runx contributes to tumorigenesis of many organs. Conversely, cell- and tissue-specific tumor suppressor roles of Runx are also reported. In this review, we have provided the structural/functional properties of Runx isoforms and its regulation in context of human cancer. Moreover, in an urgent need to discover novel therapeutic interventions against cancer, we comprehensively discussed the reported oncogenic and tumor suppressive roles of Runx isoforms in several tumor types and discussed the discrepancies that may have risen on Runx as a driver of malignant transformation.

Conclusion: Runx may be a novel therapeutic target against a battery of deadly human cancers.

Citing Articles

Regulation of Biomineralization and Autophagy by the Stress-Sensing Transcription Factor CgRunx1 in Crassostrea gigas Under Daylight Ultraviolet B Radiation.

Song H, Dong M, Xu W, Xie C, Zhang Y, Huang H Mar Biotechnol (NY). 2024; 26(6):1260-1270.

PMID: 39235651 DOI: 10.1007/s10126-024-10370-4.

[Latest Findings on the Role of RUNX1 in Bone Development and Disorders].

Pan Z, Zhou X, Cao Z, Pan J Sichuan Da Xue Xue Bao Yi Xue Ban. 2024; 55(2):256-262.

PMID: 38645858 PMC: 11026898. DOI: 10.12182/20240360103.

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