[Research Progress on Long-term Developmental Outcomes of Offspring of Pregnant Women with Systemic Lupus Erythematosus]

Overview

Journal Zhongguo Dang Dai Er Ke Za Zhi

Specialty Pediatrics

Date 2023 Apr 19

PMID 37073848

Authors

Shu-Ming Shao

Yi-Min Zhang

Xiao-Rui Zhang

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and systems. It is more common in women of childbearing age. Compared with the general population, pregnant women with SLE are at a significantly increased risk of adverse perinatal outcomes such as preterm birth and intrauterine growth restriction. In addition, the offspring of SLE patients may also be adversely affected by exposure to maternal autoantibodies, cytokines, and drugs. This article summarizes the long-term developmental outcomes of offspring of pregnant women with SLE in terms of the blood system, circulatory system, nervous system, and immune system.

Citing Articles

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies.

Cai Y, Deng Z, Yang Q, Pan G, Liang Z, Yang X Front Immunol. 2024; 15:1335042.

PMID: 38357540 PMC: 10864668. DOI: 10.3389/fimmu.2024.1335042.

References

Proper S, Azouz N, Mersha T . Achieving Precision Medicine in Allergic Disease: Progress and Challenges. Front Immunol. 2021; 12:720746. PMC: 8416451. DOI: 10.3389/fimmu.2021.720746. View

Andreoli L, Lazzaroni M, Carini C, DallAra F, Nalli C, Reggia R . "Disease knowledge index" and perspectives on reproductive issues: A nationwide study on 398 women with autoimmune rheumatic diseases. Joint Bone Spine. 2018; 86(4):475-481. DOI: 10.1016/j.jbspin.2018.12.002. View

Turgeon S, Lanovaz M, Dufour M . Effects of an Interactive Web Training to Support Parents in Reducing Challenging Behaviors in Children with Autism. Behav Modif. 2020; 45(5):769-796. DOI: 10.1177/0145445520915671. View

Nalli C, Galli J, Lazzaroni M, Andreoli L, Fazzi E, Tincani A . Long-term outcome of children born from mothers with autoimmune diseases. Best Pract Res Clin Obstet Gynaecol. 2019; 64:107-116. DOI: 10.1016/j.bpobgyn.2019.11.003. View

Vinet E, Pineau C, Scott S, Clarke A, Platt R, Bernatsky S . Increased congenital heart defects in children born to women with systemic lupus erythematosus: results from the offspring of Systemic Lupus Erythematosus Mothers Registry Study. Circulation. 2014; 131(2):149-56. DOI: 10.1161/CIRCULATIONAHA.114.010027. View

He H, Yu Y, Liew Z, Gissler M, Laszlo K, Valdimarsdottir U . Association of Maternal Autoimmune Diseases With Risk of Mental Disorders in Offspring in Denmark. JAMA Netw Open. 2022; 5(4):e227503. PMC: 9012963. DOI: 10.1001/jamanetworkopen.2022.7503. View

Neri F, Chimini L, Bonomi F, Filippini E, Motta M, Faden D . Neuropsychological development of children born to patients with systemic lupus erythematosus. Lupus. 2004; 13(10):805-11. DOI: 10.1191/0961203304lu2018oa. View

Couture J, Bernatsky S, Scott S, Pineau C, Vinet E . Brief Report: Risk of Childhood Rheumatic and Nonrheumatic Autoimmune Diseases in Children Born to Women With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2018; 70(11):1796-1800. DOI: 10.1002/art.40570. View

Stockfelt M, Larsson G, Engstrom H, Puttonen H, Zetterberg H, Blennow K . Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies. Lupus Sci Med. 2021; 8(1). PMC: 7942245. DOI: 10.1136/lupus-2020-000463. View

10.

Ross G, Sammaritano L, Nass R, Lockshin M . Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med. 2003; 157(4):397-402. DOI: 10.1001/archpedi.157.4.397. View

11.

Zhu Z, Tang S, Deng X, Wang Y . Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis. J Autism Dev Disord. 2020; 50(8):2852-2859. DOI: 10.1007/s10803-020-04400-y. View

12.

Wu C, Chen C, Lin S, Weng C, Kuo P, Shieh C . Increased risk of early-onset childhood systemic lupus erythematosus for children born to affected parents: A nationwide child-parent cohort study. Front Immunol. 2022; 13:966809. PMC: 9483159. DOI: 10.3389/fimmu.2022.966809. View

13.

Tsai P, Yu K, Chou I, Luo S, Tseng W, Huang L . Risk of autism spectrum disorder in children born to mothers with systemic lupus erythematosus and rheumatoid arthritis in Taiwan. Joint Bone Spine. 2017; 85(5):599-603. DOI: 10.1016/j.jbspin.2017.11.005. View

14.

Gengoux G, Schwartzman J, Millan M, Schuck R, Ruiz A, Weng Y . Enhancing Social Initiations Using Naturalistic Behavioral Intervention: Outcomes from a Randomized Controlled Trial for Children with Autism. J Autism Dev Disord. 2021; 51(10):3547-3563. DOI: 10.1007/s10803-020-04787-8. View

15.

Marder W, Romero V, Ganser M, Hyzy M, Gordon C, McCune W . Increased usage of special educational services by children born to mothers with systemic lupus erythematosus and antiphospholipid antibodies. Lupus Sci Med. 2014; 1(1):e000034. PMC: 4213825. DOI: 10.1136/lupus-2014-000034. View

16.

Davidov D, Sheiner E, Wainstock T, Miodownik S, Pariente G . Maternal Systemic Lupus Erythematosus (SLE) High Risk for Preterm Delivery and Not for Long-Term Neurological Morbidity of the Offspring. J Clin Med. 2021; 10(13). PMC: 8269125. DOI: 10.3390/jcm10132952. View

17.

Knudsen S, Simard J, Knudsen J, Christensen J, Laursen T, Deleuran B . Systemic lupus erythematosus during pregnancy is not associated with school performance in offspring - A Danish population-based study. Lupus. 2020; 30(2):228-237. DOI: 10.1177/0961203320973076. View

18.

Wu Y, Espinosa K, Barnett S, Kapse A, Quistorff J, Lopez C . Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months. JAMA Netw Open. 2022; 5(4):e229244. PMC: 9055453. DOI: 10.1001/jamanetworkopen.2022.9244. View

19.

Sandoval-Valdez D, Silveira L, Rodriguez E . Cardiovascular risk in the postnatal life of children born to women with systemic lupus erythematous. Arch Cardiol Mex. 2022; 92(4):522-529. PMC: 9681509. DOI: 10.24875/ACM.21000063. View

20.

Vinet E, Pineau C, Clarke A, Scott S, Fombonne E, Joseph L . Increased Risk of Autism Spectrum Disorders in Children Born to Women With Systemic Lupus Erythematosus: Results From a Large Population-Based Cohort. Arthritis Rheumatol. 2015; 67(12):3201-8. DOI: 10.1002/art.39320. View