Interactions of BDNF Val66met and Dietary Indices in Relation to Metabolic Markers Among Patient with Type 2 Diabetes Mellitus: a Cross-sectional Study

Overview

Journal J Health Popul Nutr

Publisher Biomed Central

Specialties Nutritional Sciences
Public Health

Date 2023 Apr 19

PMID 37072879

Authors

Zeinab Naeini

Faezeh Abaj

Masoumeh Rafiee

Fariba Koohdani

Affiliations

Soon will be listed here.

Abstract

Background: Gene-diet interaction is related to the progression of diabetes and cardiovascular diseases biomarkers. We aimed to evaluate the interaction between diet quality indices and BDNF Val66Mat (rs6265) on cardiometabolic markers among diabetic patients.

Methods: This cross-sectional study was conducted on 634 patients with type 2 diabetes mellitus, which were randomly recruited from diabetic centers in Tehran. Dietary intakes were estimated by a previously validated semi-quantitative food frequency questionnaire comprising 147 items. All participants were categorized into three categories, based on healthy eating index (HEI), diet quality index (DQI), and phytochemical index (PI) scores. Polymerase chain reaction was used for genotyping the BDNF Val66Met. Interactions were tested using analysis of covariance in adjusted and crude models.

Results: Our result showed that higher DQI, HEI, and PI scores significantly decrease body mass index and waist circumference among individuals with Met/Met, Val/Met, and Val/Val genotypes (P interactions < 0.05). Moreover, the highest quartile of the DQI and PI, compared to the lowest, showed lower TG level among Met allele carriers compared to Val/Val homozygotes (P interaction = 0.004 and 0.01, respectively) and a faster reduction in IL-18 and TC level was seen among Met/Met, Val/Met who had higher HEI intake than those with Val/Val genotype.

Conclusions: BDNF Val66Met polymorphism may interact with HEI, DQI, and PI. We have revealed that Met allele acts as a protective allele for diabetic patients and may have a beneficial influence on cardio-metabolic factors through regulating dietary intake.

Citing Articles

The BDNF Val66Met polymorphism serves as a potential marker of body weight in patients with psychiatric disorders.

Zhang Y, Wei X, Zhang W, Jin F, Cao W, Yue M AIMS Neurosci. 2024; 11(2):188-202.

PMID: 38988887 PMC: 11230859. DOI: 10.3934/Neuroscience.2024012.

Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus.

Ramos-Lopez O World J Diabetes. 2024; 15(2):142-153.

PMID: 38464367 PMC: 10921165. DOI: 10.4239/wjd.v15.i2.142.

Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies.

Horvat A, Vlasic I, Stefulj J, Orsolic N, Jazvinscak Jembrek M Life (Basel). 2023; 13(12).

PMID: 38137892 PMC: 10744738. DOI: 10.3390/life13122291.

References

Krabbe K, Nielsen A, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C . Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2006; 50(2):431-8. DOI: 10.1007/s00125-006-0537-4. View

Apgar J, Shively C, Tarka Jr S . Digestibility of cocoa butter and corn oil and their influence on fatty acid distribution in rats. J Nutr. 1987; 117(4):660-5. DOI: 10.1093/jn/117.4.660. View

Dooley L, Ganz P, Cole S, Crespi C, Bower J . Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. J Affect Disord. 2016; 197:43-50. PMC: 4836957. DOI: 10.1016/j.jad.2016.02.059. View

Rashidipour-Fard N, Karimi M, Saraf-Bank S, Baghaei M, Haghighatdoost F, Azadbakht L . Healthy eating index and cardiovascular risk factors among Iranian elderly individuals. ARYA Atheroscler. 2017; 13(2):56-65. PMC: 5628852. View

Daily J, Park S . Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults. Nutrition. 2016; 33:187-194. DOI: 10.1016/j.nut.2016.07.001. View

Rafiee M, Sotoudeh G, Djalali M, Alvandi E, Eshraghian M, Javadi F . The interaction between apolipoprotein B insertion/deletion polymorphism and macronutrient intake on lipid profile and serum leptin and ghrelin levels in type 2 diabetes mellitus patients. Eur J Nutr. 2018; 58(3):1055-1065. DOI: 10.1007/s00394-018-1621-5. View

Chen G, Koh W, Neelakantan N, Yuan J, Qin L, van Dam R . Diet Quality Indices and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study. Am J Epidemiol. 2018; 187(12):2651-2661. PMC: 6887680. DOI: 10.1093/aje/kwy183. View

Boren J, Lee I, Zhu W, Arnold K, Taylor S, Innerarity T . Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100. J Clin Invest. 1998; 101(5):1084-93. PMC: 508660. DOI: 10.1172/JCI1847. View

Gyorkos A, Baker M, Miutz L, Lown D, Jones M, Houghton-Rahrig L . Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial. Cureus. 2019; 11(9):e5604. PMC: 6822553. DOI: 10.7759/cureus.5604. View

10.

DAYTON S, Hashimoto S, Dixon W, PEARCE M . Composition of lipids in human serum and adipose tissue during prolonged feeding of a diet high in unsaturated fat. J Lipid Res. 1966; 7(1):103-11. View

11.

Vidovic V, Maksimovic N, Novakovic I, Damnjanovic T, Jekic B, Vidovic S . Association of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Body Mass Index, Fasting Glucose Levels and Lipid Status in Adolescents. Balkan J Med Genet. 2020; 23(1):77-82. PMC: 7474215. DOI: 10.2478/bjmg-2020-0004. View

12.

Tande D, Magel R, Strand B . Healthy Eating Index and abdominal obesity. Public Health Nutr. 2009; 13(2):208-14. DOI: 10.1017/S1368980009990723. View

13.

McCarty M . Proposal for a dietary "phytochemical index". Med Hypotheses. 2004; 63(5):813-7. DOI: 10.1016/j.mehy.2002.11.004. View

14.

Quatromoni P, Pencina M, Cobain M, Jacques P, DAgostino R . Dietary quality predicts adult weight gain: findings from the Framingham Offspring Study. Obesity (Silver Spring). 2006; 14(8):1383-91. DOI: 10.1038/oby.2006.157. View

15.

Marosi K, Mattson M . BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2013; 25(2):89-98. PMC: 3915771. DOI: 10.1016/j.tem.2013.10.006. View

16.

Abaj F, Rafiee M, Koohdani F . Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults. Sci Rep. 2021; 11(1):15906. PMC: 8342557. DOI: 10.1038/s41598-021-95359-y. View

17.

Kadam I, Neupane S, Wei J, Fullington L, Li T, An R . A Systematic Review of Diet Quality Index and Obesity among Chinese Adults. Nutrients. 2021; 13(10). PMC: 8538294. DOI: 10.3390/nu13103555. View

18.

Tudor L, Konjevod M, Nikolac Perkovic M, Strac D, Nedic Erjavec G, Uzun S . Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder. Front Psychiatry. 2018; 9:637. PMC: 6277864. DOI: 10.3389/fpsyt.2018.00637. View

19.

Liu X, Zhu Z, Kalyani M, Janik J, Shi H . Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats. Physiol Behav. 2014; 130:99-107. PMC: 4041709. DOI: 10.1016/j.physbeh.2014.03.028. View

20.

Asghari G, Mirmiran P, Rashidkhani B, Asghari-Jafarabadi M, Mehran M, Azizi F . The association between diet quality indices and obesity: Tehran Lipid and Glucose Study. Arch Iran Med. 2012; 15(10):599-605. DOI: 0121510/AIM.005. View