Cervical Cancer in the Pregnant Population

Overview

Journal Abdom Radiol (NY)

Publisher Springer

Specialties Gastroenterology
Radiology

Date 2023 Apr 18

PMID 37071123

Authors

Trinh Nguyen

Stephanie Nougaret

Patricia Castillo

Rajmohan Paspulati

Priya Bhosale

Affiliations

Soon will be listed here.

Abstract

Cervical cancer is the second most encountered cancer in pregnant patients. The 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer updated the staging of primary cervical carcinoma and disease process, with formal incorporation of imaging as a vital source of information in the management process to improve accuracy. Diagnosis and treatment of the pregnant population is a complex interplay of achieving adequate diagnostic information and optimal treatment while minimizing toxicity and risks to the mother and fetus. While novel imaging techniques and anticancer therapies are rapidly developed, much information on the safety and feasibility of different therapies is not yet available in the pregnant population. Therefore, managing pregnant patients with cervical cancer is complex and requires a multidisciplinary approach.

References

de Haan J, Verheecke M, Van Calsteren K, Van Calster B, Shmakov R, Gziri M . Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol. 2018; 19(3):337-346. DOI: 10.1016/S1470-2045(18)30059-7. View

van Calsteren K, Vergote I, Amant F . Cervical neoplasia during pregnancy: diagnosis, management and prognosis. Best Pract Res Clin Obstet Gynaecol. 2005; 19(4):611-30. DOI: 10.1016/j.bpobgyn.2005.03.002. View

Duggan B, Muderspach L, Roman L, Curtin J, DABLAING 3rd G, Morrow C . Cervical cancer in pregnancy: reporting on planned delay in therapy. Obstet Gynecol. 1993; 82(4 Pt 1):598-602. View

Nguyen C, Montz F, Bristow R . Management of stage I cervical cancer in pregnancy. Obstet Gynecol Surv. 2000; 55(10):633-43. DOI: 10.1097/00006254-200010000-00022. View

Zemlickis D, Lishner M, Degendorfer P, Panzarella T, Sutcliffe S, Koren G . Maternal and fetal outcome after invasive cervical cancer in pregnancy. J Clin Oncol. 1991; 9(11):1956-61. DOI: 10.1200/JCO.1991.9.11.1956. View

Lee R, NEGLIA W, Park R . Cervical carcinoma in pregnancy. Obstet Gynecol. 1981; 58(5):584-9. View

Baldauf J, Dreyfus M, Ritter J, Philippe E . Colposcopy and directed biopsy reliability during pregnancy: a cohort study. Eur J Obstet Gynecol Reprod Biol. 1995; 62(1):31-6. DOI: 10.1016/0301-2115(95)02178-a. View

Bhatla N, Aoki D, Sharma D, Sankaranarayanan R . Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018; 143 Suppl 2:22-36. DOI: 10.1002/ijgo.12611. View

Speiser D, Kohler C, Schneider A, Mangler M . Radical vaginal trachelectomy: a fertility-preserving procedure in early cervical cancer in young women. Dtsch Arztebl Int. 2013; 110(17):289-95. PMC: 3651944. DOI: 10.3238/arztebl.2013.0289. View

10.

Grigsby P . PET/CT imaging to guide cervical cancer therapy. Future Oncol. 2009; 5(7):953-8. DOI: 10.2217/fon.09.70. View

11.

Pano B, Sebastia C, Ripoll E, Paredes P, Salvador R, Bunesch L . Pathways of lymphatic spread in gynecologic malignancies. Radiographics. 2015; 35(3):916-45. DOI: 10.1148/rg.2015140086. View

12.

Aoki Y, Sasaki M, Watanabe M, Sato T, Tsuneki I, Aida H . High-risk group in node-positive patients with stage IB, IIA, and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation. Gynecol Oncol. 2000; 77(2):305-9. DOI: 10.1006/gyno.2000.5788. View

13.

Odunsi K, Lele S, Ghamande S, Seago P, Driscoll D . The impact of pre-therapy extraperitoneal surgical staging on the evaluation and treatment of patients with locally advanced cervical cancer. Eur J Gynaecol Oncol. 2002; 22(5):325-30. View

14.

Yang W, Lam W, Yu M, Cheung T, Metreweli C . Comparison of dynamic helical CT and dynamic MR imaging in the evaluation of pelvic lymph nodes in cervical carcinoma. AJR Am J Roentgenol. 2000; 175(3):759-66. DOI: 10.2214/ajr.175.3.1750759. View

15.

Gui B, Cambi F, Micco M, Sbarra M, Petta F, Autorino R . MRI in pregnant patients with suspected abdominal and pelvic cancer: a practical guide for radiologists. Diagn Interv Radiol. 2020; 26(3):183-192. PMC: 7239363. DOI: 10.5152/dir.2019.19343. View

16.

Amant F, Berveiller P, Boere I, Cardonick E, Fruscio R, Fumagalli M . Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting. Ann Oncol. 2019; 30(10):1601-1612. DOI: 10.1093/annonc/mdz228. View

17.

Park J, Kim C, Park S, Park B . Parametrial invasion in cervical cancer: fused T2-weighted imaging and high-b-value diffusion-weighted imaging with background body signal suppression at 3 T. Radiology. 2014; 274(3):734-41. DOI: 10.1148/radiol.14140920. View

18.

Liu B, Gao S, Li S . A Comprehensive Comparison of CT, MRI, Positron Emission Tomography or Positron Emission Tomography/CT, and Diffusion Weighted Imaging-MRI for Detecting the Lymph Nodes Metastases in Patients with Cervical Cancer: A Meta-Analysis Based on 67 Studies. Gynecol Obstet Invest. 2017; 82(3):209-222. DOI: 10.1159/000456006. View

19.

Yu K, Hricak H, Subak L, Zaloudek C, Powell C . Preoperative staging of cervical carcinoma: phased array coil fast spin-echo versus body coil spin-echo T2-weighted MR imaging. AJR Am J Roentgenol. 1998; 171(3):707-11. DOI: 10.2214/ajr.171.3.9725301. View

20.

Engelaere C, Poncelet E, Durot C, Dohan A, Rousset P, Hoeffel C . Pelvic MRI: Is Endovaginal or Rectal Filling Needed?. Korean J Radiol. 2018; 19(3):397-409. PMC: 5904466. DOI: 10.3348/kjr.2018.19.3.397. View