A Model-based System for Assessing Ventricular Chamber Pressure-volume-dimension Relationship: Regional and Global Deformation

Overview

Journal Ann Biomed Eng

Specialty Biomedical Engineering

Date 1986 Jan 1

PMID 3706853

Authors

J Y Kresh

S K BROCKMAN

Affiliations

Soon will be listed here.

Abstract

A system has been developed for measuring and relating in a non-beating isolated canine left ventricle dynamic changes in chamber pressure, volume, diameter, regional segment length, and wall thickness. The measurement system consists of a pulsatile blood pump whose stroke-volume and frequency can be adjusted selectively. The external pump system is used as a primary means for controlling instantaneous intraventricular volume. The relationship between left ventricular volume change, intraventricular pressure, minor axis diameter, and regional dimensions were studied as a function of pump rate. In addition to the basic constitutive properties, this system provided the means for measuring and comparing regional and global pressure-strain relationship including the effect of strain rate and its relationship to viscoelastic myocardial muscle model. The dynamic relationship between global dimensions and regional dimensions, circumferential segment length, and wall thickness were also investigated. The instantaneous relationship between intraventricular pressure resulting from periodic oscillations of chamber volume, including minor equator diameter, wall thickness, and regional segment dimensions were plotted and fitted to an exponential pressure-strain model, assuming a quasi-static large deformation. The observed difference between global and regional pressure-dimension strain stiffness coefficients can be attributed in part to basic constitutive and geometric considerations and not necessarily to the complex anisotropic or heterogeneous nature of cardiac muscle properties. This methodology provides indices which appropriately characterize the regional and global left ventricular chamber deformation and stiffness.

References

Mirsky I, Cohn P, Levine J, Gorlin R, Herman M, Kreulen T . Assessment of left ventricular stiffness in primary myocardial disease and coronary artery disease. Circulation. 1974; 50(1):128-36. DOI: 10.1161/01.cir.50.1.128. View

Glantz S, Parmley W . Factors which affect the diastolic pressure-volume curve. Circ Res. 1978; 42(2):171-80. DOI: 10.1161/01.res.42.2.171. View

Streeter Jr D, SPOTNITZ H, Patel D, ROSS Jr J, SONNENBLICK E . Fiber orientation in the canine left ventricle during diastole and systole. Circ Res. 1969; 24(3):339-47. DOI: 10.1161/01.res.24.3.339. View

Rankin J, Arentzen C, McHale P, Ling D, Anderson R . Viscoelastic properties of the diastolic left ventricle in the conscious dog. Circ Res. 1977; 41(1):37-45. DOI: 10.1161/01.res.41.1.37. View

Kresh J, BROCKMAN S . An interactive microcomputer-based graphics system for analysis of cardiodynamic function. Comput Biol Med. 1984; 14(4):419-27. DOI: 10.1016/0010-4825(84)90042-8. View

Theroux P, ROSS Jr J, Franklin D, Kemper W, Sasyama S . Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine. Circulation. 1976; 53(2):302-14. DOI: 10.1161/01.cir.53.2.302. View

Swain J, Morris K, Bruno F, COBB F . Comparison of multigated radionuclide angiography with ultrasonic sonomicrometry over a wide range of ventricular function in the conscious dog. Am J Cardiol. 1980; 46(6):976-82. DOI: 10.1016/0002-9149(80)90354-9. View

Suga H, Sagawa K . Assessment of absolute volume from diameter of the intact canine left ventricular cavity. J Appl Physiol. 1974; 36(4):496-9. DOI: 10.1152/jappl.1974.36.4.496. View

Horwitz L, BISHOP V, Stone H, STEGALL H . Continuous measurement of internal left ventricular diameter. J Appl Physiol. 1968; 24(5):738-40. DOI: 10.1152/jappl.1968.24.5.738. View

10.

Olsen C, Rankin J, Arentzen C, Ring W, McHale P, Anderson R . The deformational characteristics of the left ventricle in the conscious dog. Circ Res. 1981; 49(4):843-55. DOI: 10.1161/01.res.49.4.843. View

11.

Guntheroth W . Changes in left ventricular wall thickness during the cardiac cycle. J Appl Physiol. 1974; 36(3):308-12. DOI: 10.1152/jappl.1974.36.3.308. View

12.

Mirsky I, Parmley W . Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res. 1973; 33(2):233-43. DOI: 10.1161/01.res.33.2.233. View

13.

Kresh J, Cobanoglu M, BROCKMAN S . The intramyocardial pressure: a parameter of heart contractility. J Heart Transplant. 1985; 4(2):241-6. View

14.

Hill R, Kleinman L, Chitwood Jr W, Wechsler A . Segmental mid-wall myocardial dimensions in man recorded by sonomicrometry. J Thorac Cardiovasc Surg. 1978; 76(2):235-43. View

15.

Sasayama S, Franklin D, ROSS Jr J, Kemper W, McKown D . Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog. Am J Cardiol. 1976; 38(7):870-9. DOI: 10.1016/0002-9149(76)90800-6. View

16.

Weber K, Janicki J . The heart as a muscle--pump system and the concept of heart failure. Am Heart J. 1979; 98(3):371-84. DOI: 10.1016/0002-8703(79)90051-6. View