Effects of Intracerebroventricular MOTS-c Infusion on Thyroid Hormones and Uncoupling Proteins

Overview

Journal Biol Futur

Specialty Biology

Date 2023 Apr 17

PMID 37067760

Authors

Mehmet Refik Bahar

Suat Tekin

Asiye Beytur

Ebru Etem Onalan

Fatma Ozyalin

Cemil Colak

Suleyman Sandal

Affiliations

Soon will be listed here.

Abstract

This study was conducted to determine the possible effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins (UCPs) in rats. Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c. Hypothalamus, blood, muscle, adipose tissues samples were collected for thyrotropin-releasing hormone (TRH), UCP1 and UCP3 levels were determined by the RT-PCR and western blot analysis. Serum thyroid hormone levels were determined by the ELISA assays. MOTS-c infusion was found to increase food consumption but it did not cause any changes in the body weight. MOTS-c decreased serum TSH, T3, and T4 hormone levels. On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues. The findings obtained in the study show that central MOTS-c infusion is a directly effective agent in energy metabolism.

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