The Potential Therapeutic Roles of Rho GTPases in Substance Dependence

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2023 Apr 17

PMID 37063367

Authors

Qin Ru

Yu Wang

Enyuan Zhou

Lin Chen

Yuxiang Wu

Affiliations

Soon will be listed here.

Abstract

Rho GTPases family are considered to be molecular switches that regulate various cellular processes, including cytoskeleton remodeling, cell polarity, synaptic development and maintenance. Accumulating evidence shows that Rho GTPases are involved in neuronal development and brain diseases, including substance dependence. However, the functions of Rho GTPases in substance dependence are divergent and cerebral nuclei-dependent. Thereby, comprehensive integration of their roles and correlated mechanisms are urgently needed. In this review, the molecular functions and regulatory mechanisms of Rho GTPases and their regulators such as GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs) in substance dependence have been reviewed, and this is of great significance for understanding their spatiotemporal roles in addictions induced by different addictive substances and in different stages of substance dependence.

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