Changes in Motor Activity Level in Individuals with Frontotemporal Dementia

Overview

Journal J Neurol

Specialty Neurology

Date 2023 Apr 16

PMID 37062017

Authors

C R A Silveira

E Mitchell

M Restrepo-Martinez

K Coleman

R Ruiz-Garcia

E Finger

Affiliations

Soon will be listed here.

Abstract

Changes in motor activity are common in individuals with Frontotemporal dementia (FTD). Yet, it remains unclear why some individuals become motorically hyperactive, while others hypoactive even in early stages of the disease. This study aimed to examine the relationship between motor activity level and (1) FTD clinical subtype, and (2) cortical thickness and subcortical volumes. Eighty-two charts were retrospectively reviewed from patients meeting consensus criteria for one of the three main clinical subtypes of FTD: probable bvFTD, semantic variant Primary Progressive Aphasia (PPA), or non-fluent variant PPA. Participants were assigned to one of three groups: (1) hyperactive, (2) hypoactive, or (3) no record of change. Hyperactivity was prevalent among bvFTD (58.5%) and semantic PPA (68.8%) subtypes while hypoactivity was less common in both subtypes (29.3% and 18.8%, respectively). The majority of patients with non-fluent PPA showed no record of change in motor activity (66.7%). The analysis of cortical thickness and subcortical volumes did not identify significant associations with motor activity levels. In conclusion, increased motor activity is highly prevalent among individuals with FTD, especially bvFTD and svPPA subtypes. These findings may inform prognosis and prediction of changes in motor activity, and allow planning for appropriate environmental and behavioural interventions. Future studies with prospective, standardized longitudinal collection of information regarding the type and level of change in motor activity, including wearable measures of actigraphy, may help to further delineate the onset and progression of abnormal motor behaviours and determine neuroanatomic associations in FTD.

References

Rosen H, Allison S, Schauer G, Gorno-Tempini M, Weiner M, Miller B . Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005; 128(Pt 11):2612-25. PMC: 1820861. DOI: 10.1093/brain/awh628. View

Liu W, Miller B, Kramer J, Rankin K, Wyss-Coray C, Gearhart R . Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology. 2004; 62(5):742-8. PMC: 2367136. DOI: 10.1212/01.wnl.0000113729.77161.c9. View

Marczinski C, Davidson W, Kertesz A . A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cogn Behav Neurol. 2004; 17(4):185-90. View

Snowden J, Bathgate D, Varma A, Blackshaw A, Gibbons Z, Neary D . Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry. 2001; 70(3):323-32. PMC: 1737271. DOI: 10.1136/jnnp.70.3.323. View

Zamboni G, Huey E, Krueger F, Nichelli P, Grafman J . Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology. 2008; 71(10):736-42. PMC: 2676948. DOI: 10.1212/01.wnl.0000324920.96835.95. View

Bhatia K, Marsden C . The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain. 1994; 117 ( Pt 4):859-76. DOI: 10.1093/brain/117.4.859. View

Devinsky O, Morrell M, Vogt B . Contributions of anterior cingulate cortex to behaviour. Brain. 1995; 118 ( Pt 1):279-306. DOI: 10.1093/brain/118.1.279. View

Mega M, Cohenour R . Akinetic mutism: disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychol Behav Neurol. 1997; 10(4):254-9. View

Jahanshahi M . Willed action and its impairments. Cogn Neuropsychol. 2012; 15(6-8):483-533. DOI: 10.1080/026432998381005. View

10.

Siegel J, Snyder A, Metcalf N, Fucetola R, Hacker C, Shimony J . The circuitry of abulia: insights from functional connectivity MRI. Neuroimage Clin. 2014; 6:320-6. PMC: 4215525. DOI: 10.1016/j.nicl.2014.09.012. View

11.

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

12.

Nasreddine Z, Phillips N, Bedirian V, Charbonneau S, Whitehead V, Collin I . The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005; 53(4):695-9. DOI: 10.1111/j.1532-5415.2005.53221.x. View

13.

Mitchell E, Tavares T, Palaniyappan L, Finger E . Hoarding and obsessive-compulsive behaviours in frontotemporal dementia: Clinical and neuroanatomic associations. Cortex. 2019; 121:443-453. DOI: 10.1016/j.cortex.2019.09.012. View

14.

Fischl B, Dale A . Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A. 2000; 97(20):11050-5. PMC: 27146. DOI: 10.1073/pnas.200033797. View

15.

Fischl B, Salat D, Busa E, Albert M, Dieterich M, Haselgrove C . Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002; 33(3):341-55. DOI: 10.1016/s0896-6273(02)00569-x. View

16.

Reuter M, Rosas H, Fischl B . Highly accurate inverse consistent registration: a robust approach. Neuroimage. 2010; 53(4):1181-96. PMC: 2946852. DOI: 10.1016/j.neuroimage.2010.07.020. View

17.

Segonne F, Dale A, Busa E, Glessner M, Salat D, Hahn H . A hybrid approach to the skull stripping problem in MRI. Neuroimage. 2004; 22(3):1060-75. DOI: 10.1016/j.neuroimage.2004.03.032. View

18.

Desikan R, Segonne F, Fischl B, Quinn B, Dickerson B, Blacker D . An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006; 31(3):968-80. DOI: 10.1016/j.neuroimage.2006.01.021. View

19.

Fischl B, van der Kouwe A, Destrieux C, Halgren E, Segonne F, Salat D . Automatically parcellating the human cerebral cortex. Cereb Cortex. 2003; 14(1):11-22. DOI: 10.1093/cercor/bhg087. View

20.

Westman E, Muehlboeck J, Simmons A . Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion. Neuroimage. 2012; 62(1):229-38. DOI: 10.1016/j.neuroimage.2012.04.056. View